Myofibrillogenesis

1. Front Matter

   Pages i-xvi

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2. Assembly of Myofibrillar Proteins in Striated Muscle

   1. Front Matter

      Pages 1-1

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   2. Myofibrillogenesis in Cardiac Muscle

      • Joseph W. Sanger, Jean M. Sanger

      Pages 3-20

   3. Dynamics of Contractile Proteins Constituting Myofibrils in Living Muscle Cells

      • Yutaka Shimada, Tin Moe Nwe, Fukuko Hasebe-Kishi, Homare Suzuki

      Pages 21-39

   4. Emergence of the First Myofibrils and Targeting Mechanisms Directing Sarcomere Assembly in Developing Cardiomyocytes

      • Elisabeth Ehler, Jean-Claude Perriard

      Pages 41-58

   5. Tropomodulin: An Important Player in Cardiac Myofibrillogenesis

      • Catherine McLellan, Carol C. Gregorio

      Pages 59-69

3. Maintenance and Manipulation of Myofibrillar Organization

   1. Front Matter

      Pages 71-71

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   2. Maintaining the Fully Differentiated Cardiac Sarcomere

      • Daniel E. Michele, Joseph M. Metzger

      Pages 73-85

   3. Manipulation of Myofibrillogenesis in Whole Hearts

      • Robert W. Zajdel, Matthew D. McLean, Christopher R. Denz, Syamalima Dube, Larry F. Lemanski, Dipak K. Dube

      Pages 87-100

4. Regulation of Expression of Myofibrillar Proteins

   1. Front Matter

      Pages 101-101

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   2. Molecular Regulation of Cardiac Myofibrillogenesis: Roles of Serum Response Factor, Nkx2-5, and GATA-4

      • Robert J. Schwartz, Jorge Sepulveda, Narasimhaswamy S. Belaguli

      Pages 103-127

   3. Regulation and Organization of Human Troponin Genes

      • Paul J. R. Barton, Kimberley A. Dellow, Pankaj K. Bhavsar, Martin E. Cullen, Antony J. Mullen, Nigel J. Brand

      Pages 129-141

   4. Signal Transduction in Myofibrillogenesis, Cell Growth, and Hypertrophy

      • M. A. Q. Siddiqui, Michael Wagner, Eduardo Mascareno, Saiyid Shafiq

      Pages 143-152

   5. Cytoskeletal Gene Expression in the Developing Cardiac Conduction System

      • Robert E. Welikson, Takashi Mikawa

      Pages 153-177

5. Heart Development and Myofibrillar Organization

   1. Front Matter

      Pages 179-179

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   2. Onset of a Cardiac Phenotype in the Early Embryo

      • Leonard M. Eisenberg, Carol A. Eisenberg

      Pages 181-205

   3. Cellular, Molecular, and Developmental Studies on Heart Development in Normal and Cardiac Mutant Axolotls, Ambystoma mexicanum

      • Larry F. Lemanski, Xupei Huang, R. W. Zajdel, Sharon L. Lemanski, Chi Zhang, Fanyin Meng et al.

      Pages 207-222

6. Cardiomyopathy and Myofibrillar Organization

   1. Front Matter

      Pages 223-223

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   2. The Function of Normal and Familial Hypertrophic Cardiomyopathy-Associated Tropomyosin

      • Rethinasamy Prabhakar, Kathy Pieples, Ganapathy Jagatheesan, Stephanie Burge, David F. Wieczorek

      Pages 225-235

   3. Cardiomyopathies and Myofibril Abnormalities

      • Jeffrey A. Towbin, Neil E. Bowles

      Pages 237-263

Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.

• biology
• cell
• development
• embryology
• gene
• gene expression
• heart
• phenotype
• protein
• proteins
• regulation
• signal transduction
• system

• Department of Medicine and Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, USA

  Dipak K. Dube

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