Cutaneous Drug Eruptions

1. Front Matter

   Pages i-xxi

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2. The Skin and Drug Interactions

   1. Front Matter

      Pages 1-1

      PDF

   2. Immunology of Cutaneous Drug Eruptions

      • Jon A. Dyer

      Pages 3-12

   3. Principles of Diagnosis of Cutaneous Drug Eruptions

      • John C. Hall

      Pages 13-16

   4. Histopathology of Drug Reactions

      • Brian J. Hall, Beth Ruben

      Pages 17-31

   5. Principles of Treatment of Cutaneous Drug Eruptions

      • Cindy E. Owen, Jeffrey P. Callen

      Pages 33-41

3. Drug Skin Reactions and Clinical Subgroups

   1. Front Matter

      Pages 43-43

      PDF

   2. Morbilliform Drug Eruptions

      • Uzoamaka T. Ukoha, Amit G. Pandya, Arturo R. Dominguez

      Pages 45-53

   3. Drug-Induced Urticaria

      • Tarek S. Shaath, Vikas K. Patel, Anand N. Rajpara, Garth R. Fraga, Daniel J. Aires

      Pages 55-63

   4. Erythema Multiforme and Drug Reactions

      • Eric Dean Merrill, Carol W. Stanford

      Pages 65-76

   5. Drug-Induced Vasculitis

      • Shelly Rivas, Amit G. Pandya, Arturo R. Dominguez

      Pages 77-85

   6. Pigment Changes and Drug Reactions

      • Shinjita Das, A. Shadi Kourosh

      Pages 87-106

   7. Drug-Induced Photosensitivity

      • Liza Gill, Henry W. Lim

      Pages 107-121

   8. Erythema Nodosum as a Drug Eruption

      • Shilpi Khetarpal, Wilma F. Bergfeld

      Pages 123-127

   9. Lichen Planus Drug Reactions

      • Carol W. Stanford, Kaitlin Vogt Schiavo

      Pages 129-134

   10. Pityriasis Rosea-Like Drug Eruptions

       • Kaitlin Vogt Schiavo, Carol W. Stanford

       Pages 135-140

   11. Psoriasiform Drug Eruptions and Drugs That Flare Psoriasis

       • Elizabeth B. Lester, Deborah L. Cook, Gretchen W. Frieling

       Pages 141-155

   12. Acne and Drug Reactions

       • Christopher P. Schiavo, Carol W. Stanford

       Pages 157-165

   13. Collagen Vascular Diseases and Cutaneous Drug Reactions

       • Ritika Trikha, Helena R. Winston, Lindsay N. Boyers, Chante Karimkhani

       Pages 167-180

   14. Fixed Drug Eruptions

       • Kara M. Pretzlaff, Amit G. Pandya, Arturo R. Dominguez

       Pages 181-192

​The burden of cutaneous drug reactions is significant, in both outpatient and inpatient settings,  and can result in morbidity and even mortality.  This book is unique in its approach to this problem.  This text is divided into basic principles, common drug reactions, skin conditions mimicked by drug reactions, drug reactions to the skin appendages, life-threatening drug reactions, less common drug reactions, and special groupings of drug reactions. For the clinician, the skin can only morphologically react in to many limited ways. This is also true for the pathologist.  Combining these two forever linked specialties is a synergistic paradigm that greatly enhances diagnosis, and ultimately therapy, for these pernicious conditions. Drug reactions in the skin remain a common complication of therapy.  True incidences of drug reactions are not available.  For general discussion, the rule of 3% can be applied with reasonable assuredness.  Approximately 3% of all hospitalized patients develop an adverse cutaneous drug reaction.  Approximately 3% of these reactions are considered severe.  Outpatient data is even more obscure, but at least 3% of dermatology clinic outpatient visits are due to a drug reaction.  Cutaneous drug reactions compromise approximately 3% of all drug reactions. Even more challenging is the fact that the most vulnerable populations to drug reactions are increasing and include the elderly patients on prolonged drug therapy, and patients that use multiple drugs at the same time.

• Allergy
• Dermatology Drugs
• Drug reactions
• Drug safety
• Skin disease

“This book describes the pathophysiology of different drug rashes of different etiology with a special insight into drug hypersensitivity reactions. … Those physicians (allergists, dermatologists, pathologists, etc.) who desire a more in-depth look at the interaction of drugs and the skin, as well as the underlying mechanisms that lead to cutaneous drug eruptions, will find in this book a comprehensive and up-to-date valuable medical reference.” (Alberto Alvarez-Perea, World Allergy Organization WAO, worldallergy.org, January, 2016)

“This book discusses the underlying immunopathology and histology responsible for the patterns of drug rashes. … The audience is dermatologists and primary care physicians. … The authors do an outstanding job of helping track down the villainous drug. If you are interested in honing your Sherlock Holmes diagnostic skills, get this book. I plan to keep it close by.” (Patricia Wong, Doody's Book Reviews, November, 2015)

• Kansas City, USA

  John C. Hall

• Miraca Life Sciences, Irving, USA

  Brian J. Hall

Dr. John C. Hall graduated from the University of Nebraska College of Medicine in 1972. He works in Kansas City, MO and specializes in Dermatology. Dr. Hall is affiliated with Saint Lukes Hospital Of Kansas City and Truman Medical Center Hospital Hill.

Brian Hall completed his pathology residency at the University of Utah followed by a dermatopathology fellowship under Clay J. Cockerell at UT Southwestern Medical School in the Department of Dermatology. He has co-edited six dermatology and pathology textbooks with his father, John C. Hall, a well-known dermatologist in the Kansas City area.