Chest Pain with Normal Coronary Arteries

A Multidisciplinary Approach

  • Juan Carlos Kaski
  • Guy D. Eslick
  • C. Noel Bairey Merz

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introductory Chapters

    1. Front Matter
      Pages 1-1
    2. Juan Carlos Kaski, C. Noel Bairey Merz, Guy D. Eslick
      Pages 3-7
    3. Cristina Almansa, Sami R. Achem
      Pages 9-21
    4. Anisa Shaker, C. Prakash Gyawali
      Pages 23-34
  3. Epidemiology and Pathogenesis

    1. Front Matter
      Pages 35-35
    2. Rosanna Tavella, Guy D. Eslick
      Pages 37-47
    3. Leslee J. Shaw
      Pages 49-51
    4. Kamila S. White, Diane L. Rosenbaum
      Pages 53-63
    5. Gaetano Antonio Lanza, Filippo Crea
      Pages 65-78
    6. Domenico G. Della Rocca, Carl J. Pepine
      Pages 79-90
    7. Satoshi Yasuda, Hiroaki Shimokawa
      Pages 91-99
    8. John Beltrame, Peter Ganz
      Pages 101-117
  4. Microvascular Angina in Different Clinical Conditions

    1. Front Matter
      Pages 119-119
    2. Tarek Francis Antonios
      Pages 121-126
    3. Vimal Patel, Perry Elliott
      Pages 127-136
    4. Isabella Tritto, Cinzia Zuchi, Giuseppe Ambrosio
      Pages 137-148
    5. Giuseppe Vassalli, Augusto Gallino, Pierre Vogt
      Pages 149-157
    6. Ingrid E. Dumitriu, Juan Carlos Kaski
      Pages 159-166
    7. Guarini Giacinta, Mario Marzilli
      Pages 167-172

About this book


The condition known as “chest pain with normal coronary arteries” or “cardiac syndrome X” has puzzled physicians since the advent of coronary arteriography. Although epicardial coronary artery spasm, as seen in Prinzmetal’s variant angina, explains a proportion of cases of typical chest pain despite normal coronary arteriograms, many patients who seek medical attention for exertional and rest angina in the absence of obstructive coronary artery disease are not variant angina cases. This syndrome therefore constitutes both a diagnostic and therapeutic challenge.

Chest Pain with Normal Coronary Arteries has been written by many of the most active international research groups and comprehensively tackles the clinical presentation and the pathogenesis of the condition, as well as its management. Abnormalities of the coronary microcirculation have remained elusive to conventional imaging and researchers appear only recently to be making progress in obtaining much needed information in this field. The functional aspects of the coronary microcirculation, its clinical presentation and prognosis, as well as the diagnostic tests used for the assessment of microvascular dysfunction are important topics highlighted in this book, which also includes useful clinical diagnostic algorithms, thus bringing this subject closer to the practicing cardiologist. This book thus represents a practical tool for the clinician and a bank of information and new ideas for research scientists and clinical researchers interested in understanding the causes and mechanisms of the condition.


Angina Cardiology Endocrinology Gastroenterology

Editors and affiliations

  • Juan Carlos Kaski
    • 1
  • Guy D. Eslick
    • 2
  • C. Noel Bairey Merz
    • 3
  1. 1.Medical School, Coronary Artery Disease, Research GroupSt George's HospitalLondonUnited Kingdom
  2. 2.University of Sydney, Discipline of SurgeryThe Whiteley-Martin Research CentreSydneyAustralia
  3. 3., Women's Heart CenterCedars-Sinai Heart InstituteLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag London 2013
  • Publisher Name Springer, London
  • eBook Packages Medicine
  • Print ISBN 978-1-4471-4837-1
  • Online ISBN 978-1-4471-4838-8
  • About this book