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Bone Scanning in Clinical Practice

  • Ignac Fogelman

Table of contents

  1. Front Matter
    Pages i-xviii
  2. I. Fogelman
    Pages 1-6
  3. M. D. Francis, I. Fogelman
    Pages 7-17
  4. M. V. Merrick
    Pages 19-29
  5. J. H. McKillop
    Pages 41-60
  6. I. Fogelman
    Pages 73-87
  7. I. Fogelman
    Pages 89-104
  8. K. Mido, D. A. Navarro, G. M. Segall, I. R. McDougall
    Pages 105-120
  9. L. Rosenthall
    Pages 133-150
  10. L. Rosenthall
    Pages 151-174
  11. I. Gordon, A. M. Peters
    Pages 189-209
  12. H. W. Gray
    Pages 211-235
  13. Back Matter
    Pages 257-260

About this book

Introduction

The most frequently requested investigation in any nuclear medicine department remains the technetium-99m (99mTc)-labelled diphosphonate bone scan. Despite rapid advances in all imaging modalities. there has been no serious challenge to the role of bone scanning in the evaluation of the skeleton. The main reason for this is the exquisite sensitivity of the bone scan for lesion detection. combined with clear visualisation of the whole skeleton. In recent years several new diphosphonate agents have become available with claims for superior imaging of the skeleton. Essentially. they all have higher affinity for bone. thus allowing the normal skeleton to be visualised all the more clearly. However. as will be dis­ cussed. this may occur at some cost to the principal role of bone scanning. lesion detection. The major strength of nuclear medicine is its ability to provide functional and physiological information. With bone scanning this leads to high sensitivity for focal disease if there has been any disturbance of skeletal metabolism. However. in many other clinical situations. and particularly in metabolic bone disease. more generalised alteration in skeletal turnover may occur. and quantitation of diphosphonate uptake by the skeleton can provide valuable clinical information.

Keywords

bone imaging nuclear medicine

Editors and affiliations

  • Ignac Fogelman
    • 1
  1. 1.Department of Nuclear MedicineGuy’s HospitalLondonUK

Bibliographic information