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  • Book
  • © 2011

Controlled Pulmonary Drug Delivery

Editors:

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  • Brings together the fundamental theory and practice of controlled release drug delivery to the airways

  • Serves as both a reference text and a toolbox for translating our fundamental understanding into practical approaches

  • Provides a sound background on the biological barriers and opportunities for controlled release pulmonary drug delivery

  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

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USD 189.00
Price excludes VAT (USA)
  • ISBN: 978-1-4419-9745-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book
USD 249.99
Price excludes VAT (USA)
Hardcover Book
USD 349.99
Price excludes VAT (USA)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiii
  2. Macro- and Microstructure of the Airways for Drug Delivery

    • Kevin P. O’Donnell, Hugh D. C. Smyth
    Pages 1-19
  3. Pulmonary Drug Metabolism, Clearance, and Absorption

    • Bo Olsson, Eva Bondesson, Lars Borgström, Staffan Edsbäcker, Stefan Eirefelt, Katarina Ekelund et al.
    Pages 21-50
  4. Overcoming Lung Clearance Mechanisms for Controlled Release Drug Delivery

    • Ibrahim M. El-Sherbiny, Diana G. Villanueva, Dea Herrera, Hugh D. C. Smyth
    Pages 101-126
  5. Controlled Transport for Pulmonary Drug Delivery

    • Jennifer Fiegel, Timothy Brenza, Rania Hamed
    Pages 143-163
  6. Science and Technology of Pressurized Metered-Dose Inhalers

    • Sandro R. P. da Rocha, Balaji Bharatwaj, Sowmya Saiprasad
    Pages 165-201
  7. Science and Technology of Dry Powder Inhalers

    • Timothy M. Crowder, Martin J. Donovan
    Pages 203-222
  8. Science and Technology of Nebulizers and Liquid-Based Aerosol Generators

    • Aileen Gibbons, Hugh D. C. Smyth
    Pages 223-236
  9. Excipients Utilized for Modifying Pulmonary Drug Release

    • Poonam Sheth, Paul B. Myrdal
    Pages 237-263
  10. Polymers for Pulmonary Drug Delivery

    • Poonam Sheth, Paul B. Myrdal
    Pages 265-282
  11. Particle Engineering Technologies for Pulmonary Drug Delivery

    • Nashwa El-Gendy, Mark M. Bailey, Cory Berkland
    Pages 283-312
  12. Liposomes for Pulmonary Drug Delivery

    • Janani Swaminathan, Carsten Ehrhardt
    Pages 313-334
  13. Nanoparticles for Pulmonary Delivery

    • Alan B. Watts, Robert O. Williams III
    Pages 335-366
  14. Pulmonary Delivery of Plasmid DNA for Disease Prevention and Therapy

    • Simon Heuking, Gerrit Borchard
    Pages 367-381
  15. In Vitro Performance Testing for Pulmonary Drug Delivery

    • Yoen-Ju Son, Jolyon P. Mitchell, Jason T. McConville
    Pages 383-415
  16. In Vitro Cell Culture Models for Evaluating Controlled Release Pulmonary Drug Delivery

    • Stephen T. Buckley, Kwang-Jin Kim, Carsten Ehrhardt
    Pages 417-442

About this book

This distinctive text provides a toolbox for pharmaceutical scientists and those involved in product development utilizing pulmonary drug delivery systems. Uniquely focusing on aspects of control, both temporal and spatial, the text collects a broad range of interlinked chapters that provide both theoretical and practical insight.

 

Controlled Pulmonary Drug Delivery begins by examination of the foundations for pulmonary drug delivery: the macro and microstructure of the airways, lung clearance, airway absorption and transport, aerosol physics, and a historical overview of the field. Unlike other texts, these chapters are written specifically with drug delivery in mind. The science and technology of inhaler devices, technologies, materials, and particles systems are covered. Testing methods and techniques are discussed before regulatory perspectives and performance specifications conclude the text. The twenty two novel chapters in this volume each provide a theoretical and practical set of tools that comprise a comprehensive toolbox.

 

This volume will be of interest to scientists and engineers developing pulmonary drug delivery systems. The unique themes of controlled release science and technology that run through the book ensure that experienced and newcomers will greatly benefit from this book. As the importance for control over therapeutic performance is better recognized and demanded, this text will be essential for those delivering bioactives to the lung.

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

Keywords

  • Controlled
  • Delivery
  • Hickey
  • Pulmonary
  • Release
  • Science
  • Smyth
  • Technology

Editors and Affiliations

  • , Pharmaceutics Division - PHR 4.214, University of Texas, Austin, USA

    Hugh D.C. Smyth

  • Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, USA

    Anthony J. Hickey

About the editors

Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases.

Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

Bibliographic Information

Buying options

eBook
USD 189.00
Price excludes VAT (USA)
  • ISBN: 978-1-4419-9745-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 249.99
Price excludes VAT (USA)
Hardcover Book
USD 349.99
Price excludes VAT (USA)