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Sample Preparation of Pharmaceutical Dosage Forms

Challenges and Strategies for Sample Preparation and Extraction

  • Book
  • © 2011

Overview

  • Volume focused entirely on sample preparation and extraction of pharmaceutical dosage forms

  • A valuable resource in developing and troubleshooting sample preparation methods for drug products at all stages in the lifecycle of a drug product

  • Presents multiple examples and case studies to highlight various potential issues and solutions

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About this book

This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods.  These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product. 

This book is divided into four parts:

•          Part One covers dosage form and diluent properties that impact sample preparation of pharmaceutical dosage forms and the importance of sampling considerations in generating data representative of the drug product batch. 

•          Part Two reviews specific sample preparation techniques typically used with pharmaceutical dosage forms.

•          Part Three discusses sample preparation method development for different types of dosage forms including addressing drug excipient interactions and post extraction considerations, as well as method validation and applying Quality by Design (QbD) principles to sample preparation methods.  

•          Part Four examines additional topics in sample preparation including automation, investigating aberrant potency results, green chemistry considerations for sample preparation and the ideal case where no sample preparation is required for sample analysis.

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Keywords

Table of contents (15 chapters)

  1. Introduction

  2. Extraction and Sample Preparation Techniques

  3. Sample Preparation Method Development and Validation for Various Dosage Form Types

  4. Additional Sample Preparation Topics

Editors and Affiliations

  • Pfizer Global Research & Development, Analytical Research & Development Dept., Pfizer Inc., Groton, USA

    Beverly Nickerson

About the editor

Beverly Nickerson, Ph.D., is Associate Research Fellow in Analytical Development in Pfizer Global Research and Development, Pfizer Inc.  Dr. Nickerson is well published in peer-reviewed journals, is author of several book chapters and has presented at various scientific meetings.  She has extensive experience in early stage and late stage drug development.

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