Calcium Channel Pharmacology

1. Front Matter

   Pages i-xv

   PDF

2. Concepts of State-Dependent Pharmacology of Calcium Channels

   • Evgeni N. Timin, Stanislav Berjukow, Steffen Hering

   Pages 1-19

3. Pharmacology of Cav1 (L-Type) Channels

   • David J. Triggle

   Pages 21-72

4. The Therapeutic Utility of Targeting Cav2 Channels

   • Charles J. Cohen, Richard L. Kraus

   Pages 73-93

5. Peptide Toxin Inhibition of Voltage Gated Calcium Channels

   • Stefan I. McDonough

   Pages 95-142

6. Calcium Channel Blocking Polypeptides

   • Raymond S. Norton, Jonathan B. Baell, James A. Angus

   Pages 143-181

7. Pharmacology of Cav3 (T-Type) Channels

   • Eric A. Ertel

   Pages 183-236

8. Cellular Functions of Calcium Channel Subtypes

   • Erika S. Piedras-Rentería, Paul G. Mermelstein, Geoffrey S. Pitt

   Pages 237-275

9. Genetic Approaches to the Elucidation of Calcium Channel Functions in Vivo

   • Hironao Saegusa, Tsutomu Tanabe

   Pages 277-302

10. Calcium Channel Mutations and Associated Diseases

    • Yasuo Mori, Yuko Itsukaichi, Motohiro Nishida, Hiroaki Oka

    Pages 303-330

11. Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors

    • Aaron M. Beedle, Gerald W. Zamponi

    Pages 331-367

12. Alternative Splicing in Voltage Gated Calcium Channels

    • Diane Lipscombe, Andrew J. Castiglioni

    Pages 369-409

13. Back Matter

    Pages 411-418

    PDF

Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

• Calcium
• Peptide
• mutation
• pharmacology
• protein
• receptor
• research

• Marine Biological Laboratory, Woods Hole, USA

  Stefan I. McDonough

Policies and ethics