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Calcium Channel Pharmacology

  • Stefan I. McDonough

Table of contents

  1. Front Matter
    Pages i-xv
  2. Evgeni N. Timin, Stanislav Berjukow, Steffen Hering
    Pages 1-19
  3. David J. Triggle
    Pages 21-72
  4. Charles J. Cohen, Richard L. Kraus
    Pages 73-93
  5. Raymond S. Norton, Jonathan B. Baell, James A. Angus
    Pages 143-181
  6. Eric A. Ertel
    Pages 183-236
  7. Erika S. Piedras-Rentería, Paul G. Mermelstein, Geoffrey S. Pitt
    Pages 237-275
  8. Yasuo Mori, Yuko Itsukaichi, Motohiro Nishida, Hiroaki Oka
    Pages 303-330
  9. Diane Lipscombe, Andrew J. Castiglioni
    Pages 369-409
  10. Back Matter
    Pages 411-418

About this book

Introduction

Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

Keywords

Calcium Peptide mutation pharmacology protein receptor research

Editors and affiliations

  • Stefan I. McDonough
    • 1
  1. 1.Marine Biological LaboratoryWoods HoleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-9254-3
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4860-3
  • Online ISBN 978-1-4419-9254-3
  • Buy this book on publisher's site