Applications of Pharmacokinetic Principles in Drug Development

  • Rajesh Krishna

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Wayne A. Colburn, Gene Heath
    Pages 1-20
  3. Lawrence X. Yu, Christopher D. Ellison, Ajaz S. Hussain
    Pages 53-74
  4. Michael W. Sinz
    Pages 75-132
  5. Thierry Lavé, Olivier Luttringer, Patrick Poulin, Neil Parrott
    Pages 133-175
  6. David V. Prior, Alyson L. Connor, Ian R. Wilding
    Pages 177-194
  7. David Fleisher, Laurie Reynolds
    Pages 195-223
  8. Shiew-Mei Huang
    Pages 307-331
  9. Shashank Rohatagi, Nancy E. Martin, Jeffrey S. Barrett
    Pages 333-372
  10. Roger Jelliffe, Alan Schumitzky, Aida Bustad, Michael Van Guilder, Xin Wang, Robert Leary
    Pages 373-404
  11. Roger W. Jelliffe, Alan Schumitzky, Robert Leary, Andreas Botnen, Ashutosh Gandhi, Pascal Maire et al.
    Pages 477-528
  12. Back Matter
    Pages 529-550

About this book


This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become an important component understanding the drug action on the body and is becoming increasingly important in drug labeling due to it's potential for predicting drug behavior in populations that may be difficult to study in adequate numbers during drug development. The ability to correlate drug exposure to effect and model it during the drug development value chain provides valuable insight into optimizing the next steps to derive maximum information from each study. These principles and modeling techniques have resulted in an expanded and integrated view of PK and PO and have led to the expectations that we may be able to optimally design clinical trials and eventually lead us to identifying the optimal therapy for the patient, while minimizing cost and speeding up drug development. There is wide utility for the book both as a text and as a reference.


Resorption absorption development drug drug development drugs kinetics metabolism pharmacokinetics pharmacology research

Editors and affiliations

  • Rajesh Krishna
    • 1
  1. 1.Aventis Pharmaceuticals, Inc.BridgewaterUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4842-9
  • Online ISBN 978-1-4419-9216-1
  • Buy this book on publisher's site