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p53

  • Ayeda Ayed
  • Theodore Hupp

Part of the Molecular Biology Intelligence Unit book series (MBIU, volume 1)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Magali Olivier, Audrey Petitjean, Claude de Caron Fromentel, Pierre Hainaut
    Pages 1-18
  3. Dadi Jiang, Laura D. Attardi
    Pages 19-35
  4. Stéphanie Courtois, Pierre Hainaut, Claude de Caron Fromentel
    Pages 36-52
  5. Nicola J. Maclaine, Theodore Hupp
    Pages 53-64
  6. Yaara Levav-Cohen, Zehavit Goldberg, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt
    Pages 65-84
  7. Carl G. Maki
    Pages 117-126
  8. Vladana Vukojevic, Tatiana Yakovleva, Georgy Bakalkin
    Pages 127-141
  9. Karuppiah Kannan, Gideon Rechavi, David Givol
    Pages 142-159
  10. Nobuo Horikoshi
    Pages 160-177
  11. Vikram Narayan, Sarah E. Meek, Kathryn L. Ball
    Pages 178-186
  12. Back Matter
    Pages 187-189

About this book

Introduction

Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research.

Keywords

Ayed Cancer Hupp MDM2 p53 regulation

Authors and affiliations

  • Ayeda Ayed
    • 1
  • Theodore Hupp
    • 2
  1. 1.Ontario Cancer InstituteUniversity of TorontoTorontoCanada
  2. 2.Institute of Genetics and Molecular Medicine CRUK p53 Signal Transduction LaboratoriesUniversity of EdinburghEdinburghScotland, UK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-8231-5
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-8230-8
  • Online ISBN 978-1-4419-8231-5
  • Series Print ISSN 1431-0414
  • Buy this book on publisher's site