Understanding the Dynamics of Biological Systems

Lessons Learned from Integrative Systems Biology

  • Werner Dubitzky
  • Jennifer Southgate
  • Hendrik Fuß

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Conner I. Sandefur, Santiago Schnell
    Pages 1-17
  3. Neema Jamshidi, Bernhard Ø. Palsson
    Pages 19-37
  4. Karthik Raman, Nagasuma Chandra
    Pages 83-110
  5. Valentina Baldazzi, Pedro T. Monteiro, Michel Page, Delphine Ropers, Johannes Geiselmann, Hidde de Jong
    Pages 111-130
  6. Rod Smallwood
    Pages 175-194
  7. Antoine Spicher, Olivier Michel, Jean-Louis Giavitto
    Pages 195-231
  8. Back Matter
    Pages 233-238

About this book


Systems biology has risen as a direct result of the limitation of conventional (reductionistic) biology to understand complex phenomena emerging as a result of dynamic and multiscale biological interactions. By applying mathematical and computational models, systems biologists integrate the elementary processes into a coherent description that allows them to predict and characterize the systems-level properties and behavior of complex biological phenomena. As the field of systems biology matures, we are beginning to see practical answers to real biological problems. It is timely to step back and review the insight obtained from a systems biology approach by presenting an overview of current research.

The book encompasses the key disciplines of biology, mathematics, and information technology that contribute to systems biology. It introduces some of the main methods and techniques of systems biology and assesses their contributions based on case studies. The biological phenomena investigated include tissue organization, hormonal control, bacterial stress response, tumor growth and cellular metabolism. Each chapter serves simultaneously as design blueprint, user guide, research agenda and communication platform. The book is targeted at an interdisciplinary audience consisting of students, teachers, researchers, developers, and practitioners in life science, mathematics, computer science and cognate areas.



Editors and affiliations

  • Werner Dubitzky
    • 1
  • Jennifer Southgate
    • 2
  • Hendrik Fuß
    • 3
  1. 1.Nano Systems Biology Research Group, Biomedical Sciences Research InstituteUniversity of UlsterColeraineUnited Kingdom
  2. 2.Jack Birch Unit of Molecular Carcinogene, Department of BiologyUniversity of YorkYorkUnited Kingdom
  3. 3.Biomedical Sciences Research Institute, Biomedical Sciences Research InstituteUniversity of UlsterColeraineUnited Kingdom

Bibliographic information