Design and Analysis of Biomolecular Circuits

Engineering Approaches to Systems and Synthetic Biology

  • Heinz Koeppl
  • Gianluca Setti
  • Mario di Bernardo
  • Douglas Densmore

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Analysis and Simulation

    1. Front Matter
      Pages 1-1
    2. David F. Anderson, Thomas G. Kurtz
      Pages 3-42
    3. Kevin Burrage, Pamela M. Burrage, André Leier, Tatiana Marquez-Lago, Dan V. Nicolau Jr
      Pages 43-62
    4. Gheorghe Craciun, Casian Pantea, Eduardo D. Sontag
      Pages 63-72
    5. Giovanni Russo, Mario di Bernardo, Jean Jacques Slotine
      Pages 93-114
  3. Modularity and Abstraction

    1. Front Matter
      Pages 115-115
    2. Kyung Hyuk Kim, Deepak Chandran, Herbert M. Sauro
      Pages 117-138
    3. Julio Saez-Rodriguez, Holger Conzelmann, Michael Ederer, Ernst Dieter Gilles
      Pages 139-159
  4. Design and Standardization

    1. Front Matter
      Pages 201-201
    2. Deepak Chandran, Frank T. Bergmann, Herbert M. Sauro, Douglas Densmore
      Pages 203-224
    3. Jacob Beal, Andrew Phillips, Douglas Densmore, Yizhi Cai
      Pages 225-252
    4. Marc Hafner, Tatjana Petrov, James Lu, Heinz Koeppl
      Pages 253-279
    5. Michal Galdzicki, Deepak Chandran, John H. Gennari, Herbert M. Sauro
      Pages 281-293
  5. Enabling Technologies

  6. Back Matter
    Pages 395-402

About this book


This book is devoted to the design and analysis of biomolecular circuits as considered in systems biology and synthetic biology.  The aim of the book is to present in a coherent framework some of the most recent work on the analysis, simulation and design of biomolecular circuits and systems, reflecting the interdisciplinary and collaborative nature of the field. The results discussed range from how these systems should be modeled and analyzed, to how they should be physically designed and implemented.  

Drawing parallels to electronic circuit design, this book’s contents are organized to reflect what the editors believe are the important, necessary steps to build complex synthetic circuits.  Coverage includes analysis and simulation, modularity and abstraction, design and standardization, and enabling technologies. Each of these themes is organized in different chapters that are self-contained so that they can be read individually by experts but also read sequentially by someone wanting to get an overview of the field. This book is intended for computational scientists, e.g. mathematicians, physicists, computer scientist or engineers as well as for researchers from the life sciences. Every effort has been made to make the presentation accessible to a broad, multi-disciplinary audience.


Bio-molecular circuits BioBricks ChIP-chip Circuit Design Circuits and Systems DNA Synthesis Synthetic Biology Systems Biology iGEM

Editors and affiliations

  • Heinz Koeppl
    • 1
  • Gianluca Setti
    • 2
  • Mario di Bernardo
    • 3
  • Douglas Densmore
    • 4
  1. 1., Automatic Control LaboratoryETH ZurichZurichSwitzerland
  2. 2.ARCESUniversità di BolognaBolognaItaly
  3. 3.Università di Napoli Federico IINapoliItaly
  4. 4., Department of Electrical and Computer EnBoston UniversityBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Engineering
  • Print ISBN 978-1-4419-6765-7
  • Online ISBN 978-1-4419-6766-4
  • Buy this book on publisher's site