Overview
This book addresses the effects of environment on the etiology, development and the susceptibility of human cancer.
Includes supplementary material: sn.pub/extras
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Table of contents (17 chapters)
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Front Matter
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General Principles
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Front Matter
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Environment and Specific Types of Cancer
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Front Matter
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Case Studies
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Front Matter
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Keywords
About this book
Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.
Editors and Affiliations
Bibliographic Information
Book Title: Environmental Factors, Genes, and the Development of Human Cancers
Editors: Deodutta Roy, M. Tevfik Dorak
DOI: https://doi.org/10.1007/978-1-4419-6752-7
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-4419-6751-0Published: 17 September 2010
Softcover ISBN: 978-1-4899-8219-3Published: 20 October 2014
eBook ISBN: 978-1-4419-6752-7Published: 11 September 2010
Edition Number: 1
Number of Pages: XIII, 520
Topics: Cancer Research, Environmental Health, Pharmacology/Toxicology