Hereditary Colorectal Cancer

  • Miguel A. Rodriguez-Bigas
  • Raul Cutait
  • Patrick M. Lynch
  • Ian Tomlinson
  • Hans F.A. Vasen

Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 5)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. History

    1. Front Matter
      Pages 1-1
    2. Susan K. Clark, Kay F. Neale, Robin K. S. Phillips
      Pages 3-14
    3. Henry T. Lynch, Megan P. Hitchins, Trudy G. Shaw, Jane F. Lynch, Hemant Roy
      Pages 15-42
  3. Basic Sciences and Genetics

    1. Front Matter
      Pages 43-43
    2. Luis G. Carvajal-Carmona, Andrew Silver, Ian P. Tomlinson
      Pages 45-66
    3. C. Richard Boland
      Pages 67-85
    4. James R. Howe, Daniel Calva
      Pages 87-109
    5. Jeremy P. Cheadle
      Pages 133-146
    6. Richard A. Hubner, Richard S. Houlston
      Pages 147-171
  4. Pathology

    1. Front Matter
      Pages 173-173
  5. Clinical Science: Familial Adenomatous Polyposis

    1. Front Matter
      Pages 195-195
    2. James Church
      Pages 203-217
    3. Andrew Latchford, Brian Saunders
      Pages 219-237
    4. Gabriela Moeslein
      Pages 239-251
  6. Clinical Science: Hereditary Nonpolyposis Colorectal Cancer

    1. Front Matter
      Pages 269-269

About this book


Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes. Hereditary Colorectal Cancer is a comprehensive collection that documents not only Familial Adenomatous Polyposis and the Lynch syndrome, but also less understood syndromes, including the Hamartomatous Polyposis Syndromes and MutYH Associated Polyposis. Internationally recognized clinicians and researchers further delve into the evolution and potential of syndromes, genes and molecular alterations that have yet to be defined. Instrumental experts in this field of discovery were carefully selected by the section editors to create this premier reference work for clinicians, scientists and researchers confronted with the treatment and management of hereditary colorectal cancer.


Adenomas Colorectal Cancer Polyposis Tumors surgery

Editors and affiliations

  • Miguel A. Rodriguez-Bigas
    • 1
  • Raul Cutait
    • 2
  • Patrick M. Lynch
    • 3
  • Ian Tomlinson
    • 4
  • Hans F.A. Vasen
    • 5
  1. 1.M.D. Anderson Cancer Center, Surgical OncologyThe University of TexasHoustonUSA
  2. 2.Associate Professor of Surgery, Brazilian Registry of Inherited, ColorecUniversity of São Paulo Medical SchoolSao PauloBrazil
  3. 3.M.D. Anderson Cancer Center, GastroenterologyThe University of TexasHoustonUSA
  4. 4.Cancer Research UK London Research InstiMolecular and Population Genetics LaboraLondonUnited Kingdom
  5. 5.Medical Center, GastroenterologyLeiden UniversityLeidenNetherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4419-6602-5
  • Online ISBN 978-1-4419-6603-2
  • About this book