Kernicterus

  • David W. McCandless

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. David W. McCandless
    Pages 1-9
  3. David W. McCandless
    Pages 11-17
  4. David W. McCandless
    Pages 19-31
  5. David W. McCandless
    Pages 33-41
  6. David W. McCandless
    Pages 43-50
  7. David W. McCandless
    Pages 51-64
  8. David W. McCandless
    Pages 65-79
  9. David W. McCandless
    Pages 81-93
  10. David W. McCandless
    Pages 95-108
  11. David W. McCandless
    Pages 109-114
  12. David W. McCandless
    Pages 115-120
  13. David W. McCandless
    Pages 121-131
  14. David W. McCandless
    Pages 133-139
  15. David W. McCandless
    Pages 141-151
  16. David W. McCandless
    Pages 153-160
  17. David W. McCandless
    Pages 161-173
  18. David W. McCandless
    Pages 175-187
  19. David W. McCandless
    Pages 189-201
  20. David W. McCandless
    Pages 203-208

About this book

Introduction

Kernicterus is an excellent example of a metabolic encephalopathy. It clearly produces a biochemical lesion early when bilirubin first enters the brain. If initial staining can be minimized or reversed, permanent damage can be avoided. This takes strict attention to detail, and a keen ability for timely and accurate diagnosis. The potential for improvement/reversal argues strongly for increased awareness by all health care workers.

Kernicterus will examine the history, biochemistry, physiology, neuropathology, etc., of bilirubin. New concepts of how bilirubin is toxic, and damages the acoustic system will be thoroughly examined. The promising new treatment possibility using gene therapy will be examined in detail. This therapy has been successfully used in the excellent animal model, the Gunn rat. Translation of these exciting results to newborn infants is well underway.

About the Author:
Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He is the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others.

Authors and affiliations

  • David W. McCandless
    • 1
  1. 1.Medicine & Science, Chicago Medical SchoolRosalind Franklin University ofNorth ChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-6555-4
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-6554-7
  • Online ISBN 978-1-4419-6555-4
  • About this book