Drug Metabolism and Pharmacokinetics Quick Guide

  • Siamak Cyrus Khojasteh
  • Harvey Wong
  • Cornelis E.C.A. Hop

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 1-15
  3. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 17-46
  4. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 47-56
  5. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 57-72
  6. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 73-95
  7. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 97-125
  8. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 127-144
  9. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 145-163
  10. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 165-181
  11. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 183-191
  12. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 193-200
  13. Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E. C. A. Hop
    Pages 201-205
  14. Back Matter
    Pages 207-214

About this book

Introduction

Drug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology.

This guide provides, for the first time, a completely integrated look at multiple aspects of absorption, distribution, metabolism, and excretion (ADME) science in a summary format that is clear, concise and self-explanatory.

This book will be used and referenced frequently as it provides detailed figures and tables for data interpretation. Also included are brief yet relevant factoids that bring a real-world dimension to the discussion of drug metabolism and pharmacokinetics.

Key topics covered:

1. Pharmacokinetics

2. Drug metabolizing enzymes

3. Oral absorption

4. Transporters

5. Metabolism-based drug interactions

6. Biotransformation and bioactivation

7. Prediction of human pharmacokinetics

8. Bioanalysis

9. Physicochemical properties and drug-like properties

10. In silico tools

11. Approved drugs

12. Chemical nomenclature

Keywords

Drug Guide Hop Khojasteh Metabolism Pharmacokinetic Quick Wong

Authors and affiliations

  • Siamak Cyrus Khojasteh
    • 1
  • Harvey Wong
    • 2
  • Cornelis E.C.A. Hop
    • 3
  1. 1.Genentech Inc.San FranciscoUSA
  2. 2.Genentech, Inc.San FranciscoUSA
  3. 3.Genentech, Inc.San FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-5629-3
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-5628-6
  • Online ISBN 978-1-4419-5629-3
  • About this book