Gene Expression and Its Discontents

The Social Production of Chronic Disease

  • Rodrick Wallace
  • Deborah Wallace

Table of contents

  1. Front Matter
    Pages i-vii
  2. Rodrick Wallace, Deborah Wallace
    Pages 1-26
  3. Rodrick Wallace, Deborah Wallace
    Pages 27-35
  4. Rodrick Wallace, Deborah Wallace
    Pages 37-43
  5. Rodrick Wallace, Deborah Wallace
    Pages 45-57
  6. Rodrick Wallace, Deborah Wallace
    Pages 59-67
  7. Rodrick Wallace, Deborah Wallace
    Pages 69-71
  8. Rodrick Wallace, Deborah Wallace
    Pages 73-97
  9. Rodrick Wallace, Deborah Wallace
    Pages 99-109
  10. Rodrick Wallace, Deborah Wallace
    Pages 111-119
  11. Rodrick Wallace, Deborah Wallace
    Pages 121-142
  12. Rodrick Wallace, Deborah Wallace
    Pages 143-160
  13. Deborah Wallace, Sandro Galea, Jennifer Ahern, Rodrick Wallace
    Pages 161-180
  14. Rodrick Wallace, Deborah Wallace
    Pages 181-182
  15. Rodrick Wallace, Deborah Wallace
    Pages 183-200
  16. Rodrick Wallace, Deborah Wallace
    Pages 201-224
  17. Back Matter
    Pages 1-3

About this book

Introduction

A cognitive paradigm for gene expression, via the asymptotic limit theorems of information theory, allows better understanding of how embedding context affects the development of organisms. In sum, epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. The authors show how environmental stressors, in a large sense, can induce a broad spectrum of developmental dysfunctions, and examine a number of pandemic chronic diseases, using U.S. data at different scales on the effects of the legacy of slavery compounded by accelerating industrial and urban decay. Developmental disorders, broadly taken, are unlikely to respond to medical interventions in the face of serious, persistent individual and community stress. In particular, drugs powerful enough to affect deleterious epigenetic programming will likely trigger side effects leading to shortened lifespan. The address of pandemic chronic disease requires significant large-scale changes in public policy and resource allocation.

Keywords

AIDS Cancer Epidemiology Obesity gene expression genes genetic epidemiology

Authors and affiliations

  • Rodrick Wallace
    • 1
  • Deborah Wallace
    • 2
  1. 1.Division of EpidemiologyNew York State Psychiatric InstituteNew YorkU.S.A.
  2. 2.New YorkU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-1482-8
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-1481-1
  • Online ISBN 978-1-4419-1482-8
  • About this book