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  • © 2010

Hippocampal Microcircuits

A Computational Modeler's Resource Book

  • Microcircuits, excitatory, inhibitory, hippocampus

Part of the book series: Springer Series in Computational Neuroscience (NEUROSCI, volume 5)

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eBook USD 219.00
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  • ISBN: 978-1-4419-0996-1
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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XI
  2. Experimental Background

    1. Front Matter

      Pages 1-3
    2. Connectivity of the Hippocampus

      • Menno P. Witter
      Pages 5-26
    3. Morphology of Hippocampal Neurons

      • Imre Vida
      Pages 27-67
    4. Fast and Slow GABAergic Transmission in Hippocampal Circuits

      • Marlene Bartos, Jonas-Frederic Sauer, Imre Vida, Ákos Kulik
      Pages 129-161
    5. Neuromodulation of Hippocampal Cells and Circuits

      • Stuart Cobb, J. Josh Lawrence
      Pages 187-246
    6. Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro

      • Tengis Gloveli, Nancy Kopell, Tamar Dugladze
      Pages 247-276
    7. Neuronal Activity Patterns in Anaesthetized Animals

      • Stuart Cobb, Imre Vida
      Pages 277-291
  3. Computational Analysis

    1. Front Matter

      Pages 313-316
    2. The Making of a Detailed CA1 Pyramidal Neuron Model

      • Panayiota Poirazi, Eleftheria-Kyriaki Pissadaki
      Pages 317-352
    3. CA3 Cells: Detailed and Simplified Pyramidal Cell Models

      • Michele Migliore, Giorgio A. Ascoli, David B. Jaffe
      Pages 353-374
    4. Entorhinal Cortex Cells

      • Erik Fransén
      Pages 375-398
    5. Single Neuron Models: Interneurons

      • Frances Skinner, Fernanda Saraga
      Pages 399-422
    6. Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuits

      • N. Kopell, C. Börgers, D. Pervouchine, P. Malerba, A. Tort
      Pages 423-457
    7. Associative Memory Models of Hippocampal Areas CA1 and CA3

      • Bruce P. Graham, Vassilis Cutsuridis, Russell Hunter
      Pages 459-494
    8. Microcircuit Model of the Dentate Gyrus in Epilepsy

      • Robert J. Morgan, Ivan Soltesz
      Pages 495-525

About this book

The hippocampus plays an indispensible role in the formation of new memories in the mammalian brain. It is the focus of intense research and our understanding of its physiology, anatomy, and molecular structure has rapidly expanded in recent years. Yet, still much needs to be done to decipher how hippocampal microcircuits are built and function. Here, we present an overview of our current knowledge and a snapshot of ongoing research into these microcircuits.

Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides focused and easily accessible reviews on various aspects of the theme. It is an unparalleled resource of information, including both data and techniques that will be an invaluable companion to all those wishing to develop computational models of hippocampal neurons and neuronal networks.

The book is divided into two main parts. In the first part, leading experimental neuroscientists discuss data on the electrophysiological, neuroanatomical, and molecular characteristics of hippocampal circuits. The various types of excitatory and inhibitory neurons are reviewed along with their connectivity and synaptic properties. Single cell and ensemble activity patterns are presented from in vitro models, as well as anesthetized and freely moving animals. In the second part, computational neuroscientists describe models of hippocampal microcircuits at various levels of complexity, from single neurons to large-scale networks. Additionally, a chapter is devoted to simulation environments currently used by computational neuroscientists in developing their models.

In addition to providing concise reviews and a wealth of data, the chapters also identify central questions and unexplored areas that will define future research in computational neuroscience.

About the Editors:

Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK. Dr. Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling. Dr. Stuart Cobb and Dr. Imre Vida are Senior Lecturers in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.

Keywords

  • Cortex
  • Radiologieinformationssystem
  • anatomy
  • behavior
  • computational neuroscience
  • declarative memories
  • hippocampus
  • microcircuits
  • neurons
  • physiology
  • synaptic properties

Reviews

From the book reviews:

“This is a current textbook on the microanatomy and physiology of the Hippocampus. … I recommend this book to neurophysiologists and anatomists.” (Joseph J. Grenier, Amazon.com, August, 2014)

“Hippocampal microcircuits: a computational modelers resource book serves to ease the process of mastering the literature within one of the most productive and active fields of neuroscience. … the book contains accessible and comprehensive reviews of experimental data on the hippocampus. … This book will prove highly valuable as a resource both for expert modelers as well as for new researcher constructing their first model of hippocampal cells and circuits.” (Michael E. Hasselmo, Frontiers in Computational Neuroscience, Vol. 5 (2), January, 2011)

“Chapters offer a treasure trove of useful up-to-date and timely information, and extensive references, that should be valuable for those who model, and also for those who do not. … In summary, this book was intended to provide a set of resources; I think the Editors and the chapter authors have done an excellent job at achieving this goal.” (Roger D. Traub, Hippocampus, 2010)

Editors and Affiliations

  • Department of Computing Science and Mathematics, University of Stirling, Stirling, UK

    Vassilis Cutsuridis, Bruce Graham

  • Neuroscience & Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK

    Stuart Cobb, Imre Vida

About the editors

Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK.
Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling.
Stuart Cobb is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.
Imre Vida is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow.

Bibliographic Information

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-1-4419-0996-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout