Advertisement

V(D)J Recombination

  • Pierre Ferrier

Part of the Advances in Experimental Medicine and Biology book series (volume 650)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Patrick C. Swanson, Sushil Kumar, Prafulla Raval
    Pages 1-15
  3. Adam G. W. Matthews, Marjorie A. Oettinger
    Pages 16-31
  4. Jean-Pierre de Villartay
    Pages 46-58
  5. Iratxe Abarrategui, Michael S. Krangel
    Pages 93-102
  6. Lance R. Thomas, Robin Milley Cobb, Eugene M. Oltz
    Pages 103-115
  7. Mary Elizabeth Jones, Yuan Zhuang
    Pages 148-156
  8. Ellen Hsu
    Pages 166-179
  9. Saïda Dadi, Sandrine Le Noir, Vahid Asnafi, Kheïra Beldjord, Elizabeth A. Macintyre
    Pages 180-194
  10. Back Matter
    Pages 195-199

About this book

Introduction

v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho­ cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.

Keywords

Antigen RNA autoimmunity dynamics genetics immunity immunoglobulin lymphocytes molecular genetics

Editors and affiliations

  • Pierre Ferrier
    • 1
  1. 1.Centre d’Immunologie de Marseille-LuminyUniversité d’Aix MarseilleMarseilleFrance

Bibliographic information