Synaptic Plasticity in Pain

  • Marzia Malcangio

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Anatomical Plasticity of Dorsal Horn Circuits

    1. Front Matter
      Pages 1-1
  3. Fast Synaptic Transmission in the Dorsal Horn

    1. Front Matter
      Pages 47-47
    2. Hanns Ulrich Zeilhofer, Robert Witschi, Torbjörn Johansson
      Pages 49-66
    3. Rachel A. Ingram, Mark L. Baccei, Maria Fitzgerald
      Pages 67-85
  4. Slow Synaptic Transmission in the Dorsal Horn

    1. Front Matter
      Pages 87-87
    2. Rita Bardoni, Adalberto Merighi
      Pages 89-108
    3. Juan Carlos Marvizon
      Pages 139-173
    4. Volker Neugebauer
      Pages 175-197
  5. Amplification of Pain-Related Information

    1. Front Matter
      Pages 199-199
    2. Stephen W. N. Thompson
      Pages 255-267
  6. Mechanisms and Targets for Chronic Pain

    1. Front Matter
      Pages 269-269
    2. Hans-Georg Schaible, Andrea Ebersberger
      Pages 271-288
    3. Fernando Cervero, Jennifer M. A. Laird
      Pages 289-306
    4. Lucy Bee, Anthony Dickenson
      Pages 307-335

About this book

Introduction

Primary sensory neurons respond to peripheral stimulation by projecting to the spinal cord, where a population of neurons respond to damaging stimuli and terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second-order neurons. It has recently become clear, however, that the strength of this first pain synapse is plastic and modifiable by several modulators--including neuronal and non-neuronal regulators--and studies on the fundamental processes regulating this plasticity have resulted in the identification of new targets for the treatment of chronic pain. With special emphasis on neuropathic pain, Synaptic Plasticity in Pain examines these targets and mechanisms for chronic pain in the dorsal horn, providing up-to-date research from the world's foremost pain experts. The book also delineates anatomical circuits for pain in the dorsal horn, explores the fast and slow transmissions at the pain synapse, and discusses how synaptic plasticity can be monitored in the dorsal horn during pain transmission.

Synaptic Plasticity in Pain is published at a time of intensive experimental research aimed at finding new mechanisms and targets for the treatment of chronic pain. This book will be of importance to a wide readership in the pain field including PhD students, doctoral scientists, and academics. It will also appeal to scientists who are interested in synaptic plasticity associated with other CNS functions, and to private sector drug discovery teams, who will find solid scientific support to their research in these pages.

 

About the Editor:

Dr. Marzia Malcangio holds a Bachelors' degree in pharmaceutical chemistry and a PhD in Pharmacology from the University of Florence, Italy. She spent most of her active scientific life in London,UK, establishing an internationally renowned laboratory devoted to the biology of spinal cord mechanisms underlying chronic pain. Her current work explores novel approaches for targeting neuropathic and arthritic pain, and the involvement of microglia and the mechanisms governing microglial-neuronal communication. Dr. Malcangio lives in London with her husband and two sons.

Keywords

cannabinoid dorsal horn glutamate nervous system neurons neuropathic opioid receptor spinal chord spinal mechanisms

Editors and affiliations

  • Marzia Malcangio

There are no affiliations available

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-0226-9
  • Copyright Information Springer-Verlag New York 2009
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-0225-2
  • Online ISBN 978-1-4419-0226-9
  • About this book