Statistics Applied to Clinical Trials

  • Ton J. Cleophas
  • Aeilko H. Zwinderman
  • Toine F. Cleophas
  • Eugene P. Cleophas

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Pages 73-79
  3. Pages 99-105
  4. Pages 185-197
  5. Pages 235-244
  6. Pages 245-261
  7. Pages 385-395
  8. Pages 479-486
  9. Pages 505-510
  10. Back Matter
    Pages 545-559

About this book


In clinical medicine appropriate statistics has become indispensable to evaluate treatment effects. Randomized controlled trials are currently the only trials that truly provide evidence-based medicine. Evidence based medicine has become crucial to optimal treatment of patients. We can define randomized controlled trials by using Christopher J. Bulpitt’s definition “a carefully and ethically designed experiment which includes the provision of adequate and appropriate controls by a process of randomization, so that precisely framed questions can be answered”. The answers given by randomized controlled trials constitute at present the way how patients should be clinically managed. In the setup of such randomized trial one of the most important issues is the statistical basis. The randomized trial will never work when the statistical grounds and analyses have not been clearly defined beforehand. All endpoints should be clearly defined in order to perform appropriate power calculations. Based on these power calculations the exact number of available patients can be calculated in order to have a sufficient quantity of individuals to have the predefined questions answered. Therefore, every clinical physician should be capable to understand the statistical basis of well performed clinical trials. It is therefore a great pleasure that Drs. T. J. Cleophas, A. H. Zwinderman, and T. F. Cleophas have published a book on statistical analysis of clinical trials. The book entitled “Statistics Applied to Clinical Trials” is clearly written and makes complex issues in statistical analysis transparant.


Analysis of variance Measure Regression analysis data analysis linear regression statistics

Editors and affiliations

  • Ton J. Cleophas
    • 1
  • Aeilko H. Zwinderman
    • 2
  • Toine F. Cleophas
    • 3
  • Eugene P. Cleophas
    • 4
  1. 1.Albert Schweitzer HospitalDordrechtThe Netherlands
  2. 2.Academic Medical CenterAmsterdamThe Netherlands
  3. 3.Damen ShipyardsGorinchemThe Netherlands
  4. 4.Technical UniversityDelftThe Netherlands

Bibliographic information