Handbook on Immunosenescence

Basic Understanding and Clinical Applications

  • Tamas Fulop
  • Claudio Franceschi
  • Katsuiku Hirokawa
  • Graham Pawelec

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Methods and Models for Studying Immunosenescence

    1. Front Matter
      Pages 2-2
    2. Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi et al.
      Pages 29-62
    3. Qing Yu, Jyoti Misra Sen, Dennis Taub
      Pages 63-85
    4. Jeff Leips
      Pages 87-105
    5. Graham Pawelec, Jürgen Kempf, Anis Larbi
      Pages 107-115
    6. Ian C. Brett, Bert E. Johansson
      Pages 117-130
    7. Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba
      Pages 131-144
    8. A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova, A. I. Yashin
      Pages 145-163
  3. Cellular Immunosenescene - T Cells

About this book


“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”


Antigen Immunosenescence and clinical applications Thymus aging cancer frailty infections metabolic syndrome senescence

Editors and affiliations

  • Tamas Fulop
    • 1
  • Claudio Franceschi
    • 2
  • Katsuiku Hirokawa
    • 3
  • Graham Pawelec
    • 4
  1. 1.Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada
  2. 2.Department of Experimental PathalogyCIG Interdepartmental Center “L. Galvani” University of BolognaBolognaItaly
  3. 3.Institute for Health and Life SciencesBunkyo-ku, TokyoJapan
  4. 4.ZMF - Zentrum Med. Forschung Abt. Transplant./ ImmunologieUniversity of TübingenTübingenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-9063-9
  • Copyright Information Springer Netherlands 2009
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4020-9062-2
  • Online ISBN 978-1-4020-9063-9
  • About this book