Current Perspectives in microRNAs (miRNA)

  • Shao-Yao Ying

Table of contents

  1. Front Matter
    Pages i-vii
  2. Piotr Kozlowski, Julia Starega-Roslan, Marta Legacz, Marcin Magnus, Wlodzimierz J. Krzyzosiak
    Pages 1-16
  3. Guiliang Tang, Yu Xiang, Zhensheng Kang, Venugopal Mendu, Xiaohu Tang, Xiaoyun Jia et al.
    Pages 17-33
  4. Akua N. Bonsra, Joshua Yonekubo, Guangwei Du
    Pages 35-50
  5. Shi-Lung Lin, David T. S. Wu, Shao-Yao Ying
    Pages 51-72
  6. Reuben Saba, Stephanie A. Booth
    Pages 73-96
  7. Mei Zhan, Chao-Zhong Song
    Pages 97-117
  8. Maya Ameyar-Zazoua, Irina Naguibneva, Linda Pritchard, Annick Harel-Bellan
    Pages 119-127
  9. Zhongliang Deng, Da-Zhi Wang
    Pages 129-144
  10. Ji Wu, Zhaojuan Yang
    Pages 145-166
  11. Keith Szulwach, Xuekun Li, Xinyu Zhao, Peng Jin
    Pages 187-204
  12. Evgeny I. Rogaev, Denis V. Islamgulov, Anastasia P. Grigorenko
    Pages 225-244
  13. Diana O. Perkins, Clark D. Jeffries
    Pages 267-281
  14. Michaela Scherr, Letizia Venturini, Matthias Eder
    Pages 305-321
  15. Chandan K. Sen, Sashwati Roy
    Pages 349-366

About this book

Introduction

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

Keywords

DNA Microarray RNA Splicing SNP cells gene expression genes miRNAs physiology tissue

Editors and affiliations

  • Shao-Yao Ying
    • 1
  1. 1.University of Southern CaliforniaLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-8533-8
  • Copyright Information Springer Science+Business Media B.V. 2008
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4020-8532-1
  • Online ISBN 978-1-4020-8533-8
  • About this book