Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

  • Alexzander A.A. Asea
  • Ian R. Brown

Part of the Heat Shock Proteins book series (HESP, volume 3)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Heat Shock Proteins and Neurodegenerative Diseases

  3. Heat Shock Proteins and Neuroprotection

  4. Extracellular Heat Shock Proteins and The Nervous System

    1. Front Matter
      Pages 255-255
    2. Michael Tytell, Mac B. Robinson, Carolanne E. Milligan
      Pages 257-272
    3. Mark R. Wilson, Justin J. Yerbury, Stephen Poon
      Pages 283-315
  5. Aging, Control Of Life Span and Expression Of Heat Shock Proteins

    1. Front Matter
      Pages 317-317

About this book

Introduction

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Keywords

Chaperones HSP Nervous System Parkinson Protein folding Stress proteins neurons

Editors and affiliations

  • Alexzander A.A. Asea
    • 1
  • Ian R. Brown
    • 2
  1. 1.Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative PathologyScott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of MedicineTempleU.S.A
  2. 2.Department of Biological SciencesCenter for the Neurobiology of Stress, University of Toronto at ScarboroughTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-8231-3
  • Copyright Information Springer Science+Business Media B.V. 2008
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4020-8230-6
  • Online ISBN 978-1-4020-8231-3
  • About this book