Overview
- Editors:
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John L. Nitiss
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St. Jude Children's Research Hospital, Memphis, USA
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Joseph Heitman
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Duke University Medical Center, Durham, USA
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Table of contents (16 chapters)
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- Julie M. Bailis, Susan L. Forsburg
Pages 1-35
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- Jennifer S. Searle, Yolanda Sanchez
Pages 37-73
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- Anita H. Corbett, Adam C. Berger
Pages 75-100
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- Nitika Thapar, Fuyuhiko Tamanoi
Pages 101-122
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- Soma S. R. Banik, Christopher M. Counter
Pages 123-139
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- Marija Tesic, Richard F. Gaber
Pages 141-177
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- Carmela Palermo, Nancy C. Walworth
Pages 179-189
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- L. Ashely Cowart, Yusuf A. Hannun, Lina M. Obeid
Pages 191-210
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- Alberto Inga, Francesca Storici, Michael A. Resnick
Pages 233-288
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- Karl Kuchler, Christoph Schüller
Pages 289-314
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- Susan L. Holbeck, Julian Simon
Pages 315-346
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- John R. Rohde, Sara A. Zurita-Martinez, Maria E. Cardenas
Pages 347-374
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- Jun O. Liu, Julian A. Simon
Pages 375-391
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- Seiko Ishida, Ira Herskowitz
Pages 393-408
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- Anna T. Rogojina, Zhengsheng Li, Karin C. Nitiss, John L. Nitiss
Pages 409-427
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Back Matter
Pages 429-433
About this book
Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.
Editors and Affiliations
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St. Jude Children's Research Hospital, Memphis, USA
John L. Nitiss
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Duke University Medical Center, Durham, USA
Joseph Heitman