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Yeast as a Tool in Cancer Research

  • John L. Nitiss
  • Joseph Heitman

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Anita H. Corbett, Adam C. Berger
    Pages 75-100
  3. Nitika Thapar, Fuyuhiko Tamanoi
    Pages 101-122
  4. Marija Tesic, Richard F. Gaber
    Pages 141-177
  5. Carmela Palermo, Nancy C. Walworth
    Pages 179-189
  6. Alberto Inga, Francesca Storici, Michael A. Resnick
    Pages 233-288
  7. Susan L. Holbeck, Julian Simon
    Pages 315-346
  8. John R. Rohde, Sara A. Zurita-Martinez, Maria E. Cardenas
    Pages 347-374
  9. Seiko Ishida, Ira Herskowitz
    Pages 393-408
  10. Back Matter
    Pages 429-433

About this book

Introduction

Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.

Keywords

Mycin Radiologieinformationssystem cancer drug discovery metabolism protein transport

Editors and affiliations

  • John L. Nitiss
    • 1
  • Joseph Heitman
    • 2
  1. 1.St. Jude Children's Research HospitalMemphisUSA
  2. 2.Duke University Medical CenterDurhamUSA

Bibliographic information