Enantiomer Separation

Fundamentals and Practical Methods

  • Fumio Toda

About this book

Introduction

In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Keywords

chromatography crystal crystallization Enantiomer high-performance liquid chromatography material Peptid peptide separation separation process synthesis

Editors and affiliations

  • Fumio Toda
    • 1
  1. 1.Okayama University of ScienceJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-2337-8
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-2336-1
  • Online ISBN 978-1-4020-2337-8
  • About this book