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Table of contents

  1. Front Matter
    Pages i-ix
  2. T. P. Flores, D. S. Moss
    Pages 1-26
  3. Leo S. D. Caves, Dzung T. Nguyen, Roderick E. Hubbard
    Pages 27-68
  4. Arun Malhotra, Robert K.-Z. Tan, Stephen C. Harvey
    Pages 107-136
  5. Mark A. Williams, Mansoor A. S. Saqi, Julia M. Goodfellow
    Pages 179-195
  6. Back Matter
    Pages 197-200

About this book

Introduction

Molecular dynamics is an important technique with applications in many areas including those of drug design, protein engineering, macromolecular structure determination and molecular recognition. This book concentrates on these exciting applications while summarizing briefly the essential mathematical background. Results are presented on protein, carbohydrate and nucleotide modelling and dynamics using the standard molecular dynamics and related algorithms. There are also chapters covering two relatively new applications namely the simulated annealing protocol which has revolutionized macromolecular structure determination from both nmr spectroscopy and x-ray crystallography and the free energy perturbation method with its direct applications relevant to the design of drugs and mutant proteins.

Keywords

biology drug design Hydra molecular biology nucleic acid Nucleotide protein protein engineering proteins RNA spectroscopy

Editors and affiliations

  • Julia M. Goodfellow
    • 1
  1. 1.Dept of CrystallographyBirkbeck CollegeLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-349-11044-5
  • Copyright Information Macmillan Publishers Limited 1991
  • Publisher Name Palgrave, London
  • eBook Packages Engineering
  • Print ISBN 978-1-349-11046-9
  • Online ISBN 978-1-349-11044-5
  • Buy this book on publisher's site