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Tau Protein

Methods and Protocols

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  • © 2024
  • Latest edition


  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2754)

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About this book

This volume explores the latest advancements and techniques to study Tau protein that include basic and advanced methods and protocols from in vitro assays to in vivo models that address the molecular and functional aspects of tau physiopathology and many of its related technical issues. The chapters in this book are organized into five parts: Part One describes conformational and functional studies of native tau protein using wet and non-wet lab protocols. Part Two looks at in vitro methods to monitor or control the formation of Tau oligomers and fibrils, and the fibrillization process. Part Three provides protocols for the characterization and in vitro introduction of post-translational modifications in Tau protein for further functional studies. Part Four describes analytical tools for the detection of Tau proteins under various forms, factors associated with Tau pathology, and MAPT gene studies.  Finally, Part Five explores cellular and in vivo models for the investigations of Tau physiopathology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Tau Proteins: Methods and Protocols, Second Edition is a valuable tool for any researcher interested in learning more about this important and developing field related to Tau protein as a relevant and attractive target for neurodegeneration therapies.


Table of contents (34 protocols)

  1. Native Tau Protein: Conformational Studies and Protein-Protein Interactions

  2. In Vitro Self-Association of Tau Protein: Oligomer and Fibril Formation

  3. Tau Post-translational Modifications

  4. Analytical Methods to Detect Tau Proteins, Mutations, and Regulatory Molecules Associated to Tau Pathology

Editors and Affiliations

  • Inserm U1167, University of Lille, Villeneuve d’Ascq Cedex, France

    Caroline Smet-Nocca

Bibliographic Information

  • Book Title: Tau Protein

  • Book Subtitle: Methods and Protocols

  • Editors: Caroline Smet-Nocca

  • Series Title: Methods in Molecular Biology

  • DOI:

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024

  • Hardcover ISBN: 978-1-0716-3628-2Published: 22 March 2024

  • Softcover ISBN: 978-1-0716-3631-2Due: 22 April 2024

  • eBook ISBN: 978-1-0716-3629-9Published: 21 March 2024

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XVIII, 608

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Chemistry/Food Science, general

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