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Thermogenic Fat

Methods and Protocols

Editors:

  • Includes cutting-edge methods and protocols

  • Provides step-by-step detail essential for reproducible results

  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2662)

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xi
  2. Determination of Adipocyte Size and Number

    • Terri A. Pietka, Nada A. Abumrad
    Pages 33-52
  3. Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated Ex Vivo

    • Michaela Veliova, Marcus J. Tol, Peter Tontonoz, Orian S. Shirihai, Marc Liesa
    Pages 53-65
  4. Assessment of Bioenergetics in BAT Mitochondria

    • Alek D. Peterlin, Jordan M. Johnson, Katsuhiko Funai
    Pages 67-75
  5. Use of Isothermal Microcalorimetry to Measure Cellular Heat Production in Thermogenic Adipocytes

    • Muhammad Hamza Bokhari, Carina Halleskog, Irina Shabalina, Tore Bengtsson
    Pages 77-85
  6. Indirect Calorimetry to Assess Energy Balance in Mice: Measurement and Data Analysis

    • William Bernard Rubio, Marissa D. Cortopassi, Alexander S. Banks
    Pages 103-115
  7. Thermogenic Phenotyping in Mice

    • Donghua Hu, Irfan J. Lodhi
    Pages 117-124
  8. Calculating Diet-Induced Thermogenesis in Mice

    • Tomomi Yamazaki
    Pages 125-133
  9. Assessment of Brown and Beige Adipose Tissue Activation in Mice Using PET/CT Imaging

    • Yu-Jen Chen, Pei-Xin Liao, Wen-Hung Kuo, Ching-Yi Chen, Shih-Torng Ding, Mei-Hui Wang
    Pages 135-145
  10. Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies

    • Biyue Zhu, Steven H. Liang, Chongzhao Ran
    Pages 147-156
  11. Use of CIDEA Reporter Mouse Model for Screening Thermogenic Fat-Activating Drugs

    • Yeonho Son, Cheoljun Choi, Yun-Hee Lee
    Pages 157-166
  12. AAV-Mediated Gene Delivery to Mouse Brown Adipose Tissue

    • Wei Huang, Rhiannon Bates, Lei Cao
    Pages 167-181
  13. Subcutaneous Transplantation of White Adipose Tissue

    • Yu-Sheng Yeh, Mari Iwase, Satoko Kawarasaki, Jungin Kwon, Astrid Rodriguez-Velez, Xiangyu Zhang et al.
    Pages 183-192
  14. Brown Adipose Tissue Transplantation

    • Subhadra Gunawardana
    Pages 193-202
  15. Isolation and Characterization of Brown Adipose Tissue T Cells

    • Ling-Ran Kong, Cheng-Chao Ruan
    Pages 203-208
  16. Isolation of Adipose Tissue Extracellular Vesicles

    • Jessica M. Sabio, Clair Crewe
    Pages 209-217

About this book

This volume presents a broad collection of state-of-the-art methods to study the biology of thermogenic fat using in vitro cell culture and animal models.  Chapters guide the readers through protocols on differentiation of human pluripotent stem cells and murine adipocyte precursors; methods for measuring mitochondrial respiration, heat generation, brown fat activation, and effects on energy metabolism in mice; and techniques for AAV-mediated gene delivery, transplantation of adipose tissue, isolation of adipose tissue immune cells and extracellular vesicles, and mass spectrometry-based profiling of brown fat lipids.  Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

 

Authoritative and cutting-edge, Thermogenic Fat: Methods and Protocols aims to be comprehensive guide for researchers in the field.

Keywords

  • obesity
  • diabetes
  • Adipocyte
  • Knockout Mouse Models
  • snRNA-seq

Editors and Affiliations

  • School of Medicine, Washington University in St. Louis, Saint Louis, USA

    Irfan J. Lodhi

Bibliographic Information

  • Book Title: Thermogenic Fat

  • Book Subtitle: Methods and Protocols

  • Editors: Irfan J. Lodhi

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-3167-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-3166-9Published: 20 April 2023

  • Softcover ISBN: 978-1-0716-3169-0Due: 04 May 2024

  • eBook ISBN: 978-1-0716-3167-6Published: 19 April 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 253

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Biomedicine, general, Physiology, Stem Cells

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access