Dopaminergic System Function and Dysfunction: Experimental Approaches

1. Front Matter

   Pages i-xiii

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2. Neuroanatomy

   1. Front Matter

      Pages 1-1

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   2. Ultrastructural Study of Dopaminergic Axon Terminals

      • Natalie Doig, Max Larsson

      Pages 3-29

   3. Quantifying Dopaminergic Innervation in Rodents Using Unbiased Stereology

      • Lauren M. Reynolds, Andrea Harée Pantoja-Urbán, Del MacGowan, Colleen Manitt, Dominique Nouel, Cecilia Flores

      Pages 31-63

   4. Dendrites Crossing Borders: Quantifying the Distribution of Individual Substantia Nigra Dopaminergic Neurons’ Dendritic Tree in Pars Compacta and Pars Reticulata

      • Rafael Ignacio Gatica, Guillermo Lazcano, Pablo Henny

      Pages 65-80

3. Cell Physiology

   1. Front Matter

      Pages 81-81

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   2. Characterizing Dopamine Transporter Mediated Uptake and Efflux in Brain Slices: A New Approach

      • Nora Awadallah, Jose A. Pino, Dimitri N. Koutzoumis, Gonzalo E. Torres

      Pages 83-99

   3. Modeling Pacemaking, Bursting, and Depolarization Block in Midbrain Dopamine Neurons

      • Christopher Knowlton, Carmen C. Canavier

      Pages 101-119

   4. Electrophysiological Characterization of Dopaminergic Neurons of the Rat Substantia Nigra Compacta

      • Marcelo Aguilar-Rivera, Rafael Ignacio Gatica, Victor Azócar, Darinka Buc, José Antonio Fuentealba-Evans

      Pages 121-146

4. Models for Addiction and Neuropsychiatric Diseases

   1. Front Matter

      Pages 147-147

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   2. Pulmonary Inhalation to Assess Effects of Coca Paste on Behavior and Dopamine Neurotransmission

      • Cecilia Scorza, José Pedro Prieto, Sara Fabius, Martín Galvalisi

      Pages 149-162

   3. Ethanol Intake on Preclinical Models: Methods of Assessment and Effects on Dopamine Signaling

      • Ricardo M. Pautassi, Aranza Wille-Bille, Macarena S. Fernández, María Carolina Fabio

      Pages 163-181

   4. Preclinical Models of THC and Nicotine Exposure During Adolescent Brain Development: Modeling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission

      • Enzo Perez-Valenzuela, Steven R. Laviolette

      Pages 183-222

   5. The MAM Model to Study the Role of Dopamine in Schizophrenia

      • X. Zhu, D. L. Uliana, A. A. Grace

      Pages 223-245

5. Circuit Level and Behavior

   1. Front Matter

      Pages 247-247

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   2. Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior

      • Philip J. Clark, Rodrigo A. España

      Pages 249-281

   3. Multi-circuit Recording in Animal Models of Parkinson's Disease

      • Ximena Paz Garcia-Nuñez, Carolina Astudillo-Valenzuela, Romulo Fuentes-Flores

      Pages 283-297

   4. Neuroimaging Human Dopamine-Related Neurophysiology Across Development

      • Ashley Parr, Bart Larsen, Finnegan Calabro, Brenden Tervo-Clemmens, Beatriz Luna

      Pages 299-326

   5. Dopaminergic Control of Actions and Habits

      • Fabien Naneix, Etienne Coutureau

      Pages 327-340

6. Back Matter

   Pages 341-344

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This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity,  in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines. 

• optogenetic control
• neuropsychiatric models
• viral vector strategies
• dopamine circuits
• in vivo functional imaging

• Escuela de Química y Farmacia y Centro Interdisciplinario de Neurociencia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile

  José Antonio Fuentealba-Evans

• Departamento de Anatomía Normal, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

  Pablo Henny

Ultrastructural Study of Dopaminergic Axon Terminals.- Quantifying Dopaminergic Innervation in Rodents Using Unbiased Stereology.- Dendrites Crossing Borders: Quantifying The Distribution of Individual Dopaminergic Neurons’ Dendritic Tree in Pars Compacta and Pars Reticulata.- Characterizing Dopamine Transporter Mediated Uptake and Efflux in Brain Slices: A New Approach.- Modeling Pacemaking, Bursting and Depolarization Block in Midbrain Dopamine Neurons.- Electrophysiological Characterization of Dopaminergic Neurons of the Rat Substantia Nigra Compacta.- Pulmonary Inhalation to Assess Effects of Coca-Paste On Behavior and Dopamine Neurotransmission.- Ethanol Intake On Preclinical Models: Methods of Assessment and Effects On Dopamine Signaling.- Preclinical models of THC and Nicotine Exposure During Adolescent Brain Development: Modelling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission.- The MAM Model to Study the Role of Dopamine in Schizophrenia.- Fast Scan Cyclic Voltammetry to Assess Dopamine Function: From Circuits to Behavior.- Multi-circuit Recording in Animal Models of Parkinson.- Neuroimaging Human Dopamine-Related Neurophysiology across Development.- Dopaminergic Control of Actions and Habits.