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  • © 2012

Sjögren’s Syndrome

Diagnosis and Therapeutics


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  • A multisystemic overview of the clinical manifestations of SS, covering all medical specialties in separate, specific chapters for each organ involved assists the reader to rapidly and easily locate the symptoms that a patient with SS may present

  • A description of the latest diagnostic techniques, patient-reported outcome questionnaires and immunological studies will prove essential for making an early diagnosis and correctly interpreting diagnostic tests, histopathological studies and antibodies

  • The inclusion of a specific section centered on prognosis and outcomes of SS patients identifies the main factors associated with a poor quality of life and the prognostic factors associated with development of cancer and death

  • Will provide an exhaustive therapeutic update, specifically focused on new agents and experimental techniques, which will inform the reader of recent advances in the therapeutic management of SS, with special emphasis on possible future agents and the provision of therapeutic guidelines for managing the main clinical situations

  • Includes supplementary material:

Buying options

USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-0-85729-947-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 149.00
Price excludes VAT (USA)
Hardcover Book
USD 149.99
Price excludes VAT (USA)

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-xx
  2. Scientific Basis

    1. Front Matter

      Pages 1-1

    1. Epidemiology

      • Yannis Alamanos, Alexandros A. Drosos
      Pages 3-9
    2. Genetics, Genomics, and Proteomics of Sjögren’s Syndrome

      • Christopher J. Lessard, John A. Ice, Jacen Maier-Moore, Courtney G. Montgomery, Hal Scofield, Kathy L. Moser
      Pages 11-31
    3. Pathogenetic Aspects of Primary Sjögren’s Syndrome

      • Athanasios G. Tzioufas, Efstathia K. Kapsogeorgou, Menelaos N. Manoussakis, Haralampos M. Moutsopoulos
      Pages 33-53
    4. Primary Sjögren’s Syndrome and Viruses

      • Manuel Ramos-Casals, Albert Bové, Rafael Belenguer, Xavier Forns, Salvatore de Vita
      Pages 55-66
    5. Etiopathogenic Role of B Cells in Primary Sjögren’s Syndrome

      • Jacques-Olivier Pers, Sophie Hillion, Gabriel Tobón, Valérie Devauchelle, Alain Saraux, Pierre Youinou
      Pages 67-82
  4. Clinical Manifestations

    1. Front Matter

      Pages 83-83

    1. Oral Involvement

      • Crispian Scully, Eleni A. Georgakopoulou
      Pages 85-106
    2. Ocular Involvement

      • Stephen C. Pflugfelder, Karyn Siemasko, Michael E. Stern
      Pages 107-120
    3. Ear, Nose, and Throat Manifestations of Sjögren’s Syndrome

      • Rohan R. Walvekar, Francis Marchal
      Pages 121-128
    4. Fatigue in Primary Sjögren’s Syndrome

      • Barbara M. Segal
      Pages 129-148
    5. Musculoskeletal Involvement

      • Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Graciela S. Alarcón
      Pages 149-155
    6. Non-Vasculitic Cutaneous Involvement

      • Hobart W. Walling, Richard D. Sontheimer
      Pages 157-171
    7. Vasculitis and Sjögren’s Syndrome

      • George E. Fragoulis, Haralampos M. Moutsopoulos, John H. Stone
      Pages 173-183
    8. Cardiovascular Involvement

      • George E. Tzelepis, Clio P. Mavragani, Haralampos M. Moutsopoulos
      Pages 185-194
    9. Pulmonary Involvement

      • Clio P. Mavragani, George E. Tzelepis, Haralampos M. Moutsopoulos
      Pages 195-208
    10. Raynaud’s Phenomenon and Sjögren’s Syndrome

      • Fredrick M. Wigley
      Pages 209-225
    11. Gastrointestinal Involvement in Primary Sjögren’s Syndrome

      • Manuel Ramos-Casals, José Rosas, Roser Solans, Margit Zeher, Peter Szodoray
      Pages 227-235
    12. Liver Involvement in Sjögren’s Syndrome

      • George E. Fragoulis, Fotini N. Skopouli, Carlo Selmi, M. Eric Gershwin
      Pages 237-246

About this book

Sjögren’s Syndrome: Diagnosis and Therapeutics provides a thorough, multisystemic overview of the clinical manifestations of Sjögren’s Syndrome. It contains chapters pertinent across the range of medical specialties that may encounter Sjögren’s Syndrome cases. Chapters are specialty-specific, for easy reference by the relevant medical specialist.
In addition to being a diagnostic guide, Sjögren’s Syndrome: Diagnosis and Therapeutics  includes a section on prognosis and outcomes of Sjögren’s Syndrome patients and provides an exhaustive therapeutic update, focused on new agents and experimental techniques. The inclusion of diagnostic/therapeutic algorithms illustrates the text with clinical photographs of the main organs involved and helps the reader to make guided diagnostic and therapeutic decisions through decision-based algorithms.


  • Sjögren's syndrome


From the reviews:

“This is a detailed examination of Sjogren’s syndrome, from pathogenesis to diagnosis and treatment of the disease. One of the book’s greatest strengths is its utility as a reference. … appropriate for students, residents, and practitioners, but especially for practicing rheumatologists. … the book is quite enjoyable and easy to read cover-to-cover. The writing is clear and the subject is covered thoroughly. … This is probably the most outstanding, authoritative book on the subject that I have encountered. Any rheumatologist could benefit from reading it.” (Jonathan Miner, Doody’s Review Service, February, 2013)

Editors and Affiliations

  • Barcelona, Surgey, Hospital Clinic, Barcelona, Spain

    Manuel Ramos-Casals

  • Massachusetts General Hospital, Boston, USA

    John H. Stone

  • National University of Athens, Athens, Greece

    Haralampos M. Moutsopoulos

About the editors

Manuel Ramos Casals, MD, PhD is a Consultant of the Department of Systemic Autoimmune Diseases, Hospital Clínic, Barcelona, Head of the "Josep Font" Laboratory of Autoimmune Diseases of the IDIBAPS, Hospital Clinic, Barcelona and Assistant Professor, Department of Medicine, University of Barcelona, Barcelona, Spain. He has published more than 100 original articles focused on Sjögren’s syndrome and related conditions, has edited 6 books on systemic autoimmune diseases and has received several national grants to investigate autoimmune diseases.

John H. Stone, MD, MPH is Clinical Director of Rheumatology, Harvard Medical School, Boston, MA, USA and the Chairman of the International Network for the Study of the Systemic Vasculitides (INSSYS). Dr Stone's research interests relate to translational investigations in systemic vasculitis. He has directed two multicenter clinical trials in Wegener's granulomatosis and antineutrophil cytoplasmic antibody-associated vasculitis, the Wegener's Granulomatosis Etanercept Trial (WGET) and the Rituximab in ANCA-associated Vasculitis (RAVE) trial. His other research efforts relate to the identification of new biomarkers through proteomic approaches, and to the development of clinical trials' outcome measures in rheumatic autoimmune diseases.

Haralampos M. Moutsopoulos, MD, FACP, FRCP is a Professor and Head of the Department of Pathophysiology, Medical School, University of Athens, Greece. He has contributed to current understanding of the clinical aspects, pathogenesis and therapy of autoimmune rheumatic disorders. He is considered a world authority on Sjögren's syndrome (autoimmune epithelitis). His scientific work is extensively cited and he has been presented with numerous national and international awards.

The Editors have extensive experience in the management of the main systemic autoimmune diseases, such as systemic lupus erythematosus, vasculitis and especially Sjögren’s syndrome. They have developed many clinical and basic research projects and, in the last 5 years, have published many reports on Sjögren’s syndrome and other autoimmune diseases in the leading journals in rheumatology and internal medicine.

Bibliographic Information

  • Book Title: Sjögren’s Syndrome

  • Book Subtitle: Diagnosis and Therapeutics

  • Editors: Manuel Ramos-Casals, John H. Stone, Haralampos M. Moutsopoulos

  • DOI:

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London Limited 2012

  • Hardcover ISBN: 978-0-85729-946-8

  • Softcover ISBN: 978-1-4471-7146-1

  • eBook ISBN: 978-0-85729-947-5

  • Edition Number: 1

  • Number of Pages: XX, 633

  • Topics: Rheumatology, Internal Medicine, General Practice and Family Medicine, Ophthalmology

Buying options

USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-0-85729-947-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 149.00
Price excludes VAT (USA)
Hardcover Book
USD 149.99
Price excludes VAT (USA)