Drug Targets in Kinetoplastid Parasites

  • Hemanta K. Majumder

Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 625)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Gaganmeet Singh, K. G. Jayanarayan, Chinmoy S. Dey
    Pages 1-8
  3. Dotan Sela, Neta Milman, Irit Kapeller, Aviad Zick, Rachel Bezalel, Nurit Yaffe et al.
    Pages 9-21
  4. R.E. Morgan, K.A. Werbovetz*
    Pages 33-47
  5. Emanuela Handman, Lukasz Kedzierski, Alessandro D. Uboldi, James W. Goding
    Pages 48-60
  6. David Horn
    Pages 81-86
  7. Sumi Mukhopadhyay nee Bandyopadhyay, Chitra Mandal
    Pages 87-102
  8. Benu Brata Das, Agneyo Ganguly, Hemanta K. Majumder
    Pages 103-115
  9. Alok Kumar Datta, Rupak Datta, Banibrata Sen
    Pages 116-132
  10. Peter J. Myler
    Pages 133-140
  11. Nicola S. Carter, Phillip Yates, Cassandra S. Arendt, Jan M. Boitz, Buddy Ullman
    Pages 141-154
  12. Back Matter
    Pages 155-157

About this book

Introduction

If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas’ disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.

Keywords

biochemistry cell chemistry death development diseases genome health metabolism parasite parasites protein proteins resistance treatment

Editors and affiliations

  • Hemanta K. Majumder
    • 1
  1. 1.Molecular Parasitology LaboratoryIndian Institute of Chemical BiologyKolkataIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-77570-8
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-77569-2
  • Online ISBN 978-0-387-77570-8
  • Series Print ISSN 0065-2598
  • About this book