PET in the Evaluation of Alzheimer's Disease and Related Disorders

1. Front Matter

   Pages i-xiv

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2. Imaging Applications in Current Clinical Practice

   1. Front Matter

      Pages 1-1

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   2. Clinical Evaluation of Dementia and When to Perform PET

      • Linda M. Ercoli, Gary W. Small

      Pages 3-31

   3. Clinical Interpretation of Brain PET Scans: Performing Visual Assessments, Providing Quantifying Data, and Generating Integrated Reports

      • Daniel H.S. Silverman

      Pages 33-48

   4. FDG PET in the Evaluation of Mild Cognitive Impairment and Early Dementia

      • Lisa Mosconi, Daniel H.S. Silverman

      Pages 49-65

   5. PET and SPECT in the Evaluation of Patients with Central Motor Disorders

      • John P. Seibyl

      Pages 67-92

3. Emerging Approaches Using PET

   1. Front Matter

      Pages 1-1

      PDF

   2. Microstructural Imaging of Neurodegenerative Changes

      • Vladimir Kepe, Sung-Cheng Huang, Gary W. Small, Nagichettiar Satyamurthy, Jorge R. Barrio

      Pages 95-117

   3. Amyloid Imaging with PET in Alzheimer’s Disease, Mild Cognitive Impairment, and Clinically Unimpaired Subjects

      • William E. Klunk, Chester A. Mathis, Julie C. Price, Steven T. DeKosky, Brian J. Lopresti, Nicholas D. Tsopelas et al.

      Pages 119-147

4. Atlas

   1. Front Matter

      Pages 1-1

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   2. Interpretive Practice Atlas

      • Daniel H.S. Silverman, Victoria Lau, Cheri Geist, Erin Siu

      Pages 151-210

5. Back Matter

   Pages 211-215

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Among all the clinical indications for which radiologists, nuclear medicine phy- cians, neurologists, neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders. This demand is driven by the sheer prevalence of those conditions, coupled with the fact that the differential diagnosis for causes of cognitive impairment is wide and often difficult to distinguish clinically. The conceptual framework by which evaluation and management of dementia is guided has evolved considerably during the last decade. Although we still are far from having ideal tests or dramatic cures for any of the established causes of dementia, our options have expanded with respect to both the diagnostic and the- peutic tools now available. In the first chapter of this book, the contribution and limitations of different elements of the clinical examination for diagnosis of cog- tive symptoms are described, and the roles of structural and functional neuroim- ing in the clinical workup are given context.

• Alzheimer
• Alzheimer's
• Dementia
• Evaluation
• PET
• positron emission tomography

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