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Mechanisms of Insulin Action

  • Book
  • © 2007

Overview

Authors:
  1. Alan R. Saltiel

    1. Department of Internal Medicine and Physiology Life Sciences Institute, The University of Michigan Medical Center, Ann Arbor, USA

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  2. Jeffrey E. Pessin

    1. Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, USA

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  • Attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states

Part of the book series: Medical Intelligence Unit (MIUN)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-ix
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  2. Insulin and IGF-I Receptor Structure and Binding Mechanism

    • Pierre De Meyts, Waseem Sajid, Jane Palsgaard, Anne-Mette Theede, Lisbeth Gauguin, Hassan Aladdin et al.
    Pages 1-32

  3. Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events

    • Robert T. Watson, Alan R. Saltiel, Jeffrey E. Pessin, Makoto Kanzaki
    Pages 33-51

  4. Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis

    • Debbie C. Thurmond
    Pages 52-70

  5. Control of Protein Synthesis by Insulin

    • Joseph F. Christian, John C. Lawrence Jr.
    Pages 71-89

  6. Hepatic Regulation of Fuel Metabolism

    • Catherine Clark, Christopher B. Newgard
    Pages 90-109

  7. Insulin Action Gene Regulation

    • Calum Sutherland, Richard M. O’ Brien, Daryl K. Granner
    Pages 110-132

  8. Insulin Action in the Islet β-Cell

    • Rohit N. Kulkarni
    Pages 133-151

  9. Central Regulation of Insulin Sensitivity

    • Silvana Obici, Rossetti Luciano
    Pages 152-167

  10. Transgenic Models of Impaired Insulin Signaling

    • Francesco Oriente, Domenico Accili
    Pages 168-184

  11. Insulin Resistance

    • C. Hamish Courtney, Jerrold M. Olefsky
    Pages 185-209

  12. Back Matter

    Pages 211-214
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Keywords

About this book

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.

Authors and Affiliations

  • Department of Internal Medicine and Physiology Life Sciences Institute, The University of Michigan Medical Center, Ann Arbor, USA

    Alan R. Saltiel

  • Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, USA

    Jeffrey E. Pessin

Bibliographic Information

  • Book Title: Mechanisms of Insulin Action

  • Authors: Alan R. Saltiel, Jeffrey E. Pessin

  • Series Title: Medical Intelligence Unit

  • DOI: https://doi.org/10.1007/978-0-387-72204-7

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag New York 2007

  • Hardcover ISBN: 978-0-387-72203-0Published: 27 June 2007

  • Softcover ISBN: 978-1-4419-2469-8Published: 07 March 2011

  • eBook ISBN: 978-0-387-72204-7Published: 05 October 2007

  • Edition Number: 1

  • Number of Pages: XI, 214

  • Topics: Endocrinology, Cell Biology, Diabetes, Cardiology

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