Nucleic Acid Switches and Sensors

  • Scott K. Silverman

Table of contents

  1. Front Matter
    Pages i-ix
  2. Artificial Nucleic Acid Switches and Sensors

    1. Front Matter
      Pages 1-1
    2. Dipankar Sen, Edward K. Y. Leung
      Pages 25-36
    3. Tan Inoue, Yoskiya Ikawa
      Pages 37-47
    4. Razvan Nutiu, Lieven P. Billen, Yingfu Li
      Pages 49-72
  3. Natural Nucleic Acid Switches and Sensors

    1. Front Matter
      Pages 73-73
    2. Oliver Mayer, Oliver Mayer, Nikolai Windbichler, Herbert Wank, Renée Schroeder
      Pages 75-86
    3. Ali Nahvi, Ronald R. Breaker
      Pages 89-106
    4. Eric Westhof, Boris François, Quentin Vicens
      Pages 107-122
  4. Back Matter
    Pages 123-125

About this book

Introduction

In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

Keywords

DNA Nucleotide RNA enzymes proteins

Authors and affiliations

  • Scott K. Silverman
    • 1
  1. 1.Department of ChemistryUniversity of Illinois at Urbana-ChampaignUrbanaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-47257-7
  • Copyright Information Springer-Verlag US 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-37491-8
  • Online ISBN 978-0-387-47257-7
  • About this book