Brain Mechanisms and Clinical Implications

  • Nobumasa Kato
  • Mitsuhiro Kawata
  • Roger K. Pitman

Table of contents

  1. Front Matter
    Pages I-XI
  2. Basic Mechanism of PTSD and Stress-Related Brain Dysfunctions

    1. Front Matter
      Pages 1-1
    2. Toru Nishikawa, Akeo Kurumaji, Takashi Ito, Asami Umino, Sumikazu Ishii
      Pages 3-11
    3. E. Ronald de Kloet, Melly S. Oitzl
      Pages 13-27
    4. Mitsuhiro Kawata, Mayumi Nishi, Ken-ichi Matsuda, Hirotaka Sakamoto, Cui Honghai, Takanori Yoshii
      Pages 29-36
    5. Shigeru Morinobu, Seiichi Tsuji, Michihiro Takahashi, David S. Russell, Jun Takahashi, Kazuhide Tanaka et al.
      Pages 37-45
    6. Shigenobu Kanba, Koutaro Kudo, Naoko Kaneko, Henny Wati, Hironobu Iguchi, Keiko Takemoto
      Pages 47-53
    7. Kazuhisa Kohda, Kunio Kato, Nobumasa Kato
      Pages 55-59
    8. Robert Adamec, Jacqueline Blundell, Kirby Strasser, Paul Burton
      Pages 61-81
    9. James L. McGaugh, Benno Roozendaal, Shoki Okuda
      Pages 89-103
    10. Katsuya Harada, Takahiro Matsuya, Takayuki Yamaji, Yoshihiro Murakami, Akihiro Noda, Hiroyuki Takamatsu et al.
      Pages 105-111
    11. Ken-ichi Honma, Ayano Yamazaki, Yoshio Ootsuki, Natsumi Noda, Sato Honma
      Pages 137-144
  3. Clinical Implications for PTSD and Perspectives in Psychiatry

    1. Front Matter
      Pages 145-145
    2. Yutaka Matsuoka, Mitsue Nagamine, Yosuke Uchitomi
      Pages 169-178
    3. Tung-Ping Su, Frank Huang-Chih Chou, Wen-Chen Ou-Yang, Pesus Chou
      Pages 179-191

About this book


Recent catastrophic events, such as the attack on the New York World Trade Center and the devastating tsunami in the Indian Ocean, have drawn increasing attention to post-traumatic stress disorder, or PTSD. Once thought of only in psychological terms, PTSD has emerged as the model mental disorder for studying the effect of the environment on human biological systems, especially the brain. This book breaks new ground by offering neuroscientific insights into PTSD and their implications for diagnosis, prevention, and treatment. The recent explosion of biological investigation into this distressing and disabling condition has been led by this volume’s authors, who range from skilled basic scientists to experienced diagnosticians and therapists. Their contributions epitomize state-of-the-art, translational research in clinical neuroscience, and will prove to be an invaluable source of reference for practitioners and researchers in this field.


brain cortex drug discovery glucocorticoids neuroimaging neuroscience pathophysiology physiology posttraumatic stress disorder psychiatric disorder psychiatry research stress trauma women

Editors and affiliations

  • Nobumasa Kato
    • 1
  • Mitsuhiro Kawata
    • 2
  • Roger K. Pitman
    • 3
  1. 1.Department of Neuropsychiatry, Faculty of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Anatomy and NeurobiologyKyoto Prefectural University of MedicineKyotoJapan
  3. 3.Harvard Medical SchoolMassachusetts General HospitalCharlestownUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Tokyo 2006
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-29566-2
  • Online ISBN 978-4-431-29567-9
  • About this book