Overview
- Editors:
-
-
Antonio Cano Sanchez
-
Department of Pediatrics Obstetrics and Gynecology School of Medicine, University of Valencia, Valencia, Spain
-
Joaquim Calaf i Alsina
-
Servei d’Obstetricia i Ginecologia, Hospital de la Santa Creu i Sant Pau, Barcelona
-
José-Luis Dueñas-Díez
-
Department of Obstetrics and Gynaecology, Hospital Universitario Virgen Macarena, School of Medicine University of Sevilla, Sevilla, Spain
- Offers an updated view of the main advances on selective estrogen receptor modulators (SERM)
- first part reviews the main basic concepts
- second part concentrates on the recent news on the many uses of SERM in clinical practice
- Includes supplementary material: sn.pub/extras
Access this book
Other ways to access
Table of contents (14 chapters)
-
Front Matter
Pages I-XVII
-
Basic Area
-
-
- B. Nicolás Díaz Chico, Domingo Navarro Bosch, Juan C. Díaz Chico, Eduardo Escrich Escriche
Pages 2-47
-
- Fernando Marín, Ma Carmen Barbancho
Pages 49-69
-
- Fernando Marín, Ma Carmen Barbancho
Pages 71-77
-
- Mario Díaz, Jorge Marrero-Alonso, Benito García Marrero, Raquel Marín, Tomás Gomez, Rafael Alonso
Pages 79-102
-
- R. Alonso, F. Marín, M. González, P. Guelmes, C. Bellido, G. Hernández et al.
Pages 103-139
-
-
Clinical Area
-
Front Matter
Pages 159-159
-
- Miguel Angel García-Pérez
Pages 161-186
-
- Adolfo Díez-Pérez, José Luis Dueñas-Díez
Pages 187-206
-
-
- Joaquim Calaf i Alsina, Antonio Cano Sanchez
Pages 239-270
-
-
- Stefano Palomba, Fulvio Zullo
Pages 291-311
-
- P. Acién, F. Quereda, M. I. Acién
Pages 313-332
-
-
Back Matter
Pages 351-357
About this book
The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Reviews
From the reviews of the first edition:
"Sanchez and colleagues have assembled a timely addition to the clinician’s library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. … Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)
Editors and Affiliations
-
Department of Pediatrics Obstetrics and Gynecology School of Medicine, University of Valencia, Valencia, Spain
Antonio Cano Sanchez
-
Servei d’Obstetricia i Ginecologia, Hospital de la Santa Creu i Sant Pau, Barcelona
Joaquim Calaf i Alsina
-
Department of Obstetrics and Gynaecology, Hospital Universitario Virgen Macarena, School of Medicine University of Sevilla, Sevilla, Spain
José-Luis Dueñas-Díez