Overview
- Editors:
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Andreas Radbruch
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Deutsches Rheumaforschungszentrum Berlin (DRFZ), Berlin, Germany
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Peter E. Lipsky
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National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA
- Discusses the complex ethiopathologies of autoimmune diseases
- Explores the broad variety of cell types and genes involved
- Shows how initiating factors in autoimmune disease can possibly be distinct from those that drive the chronic course of the disease
- Explains that the importance of an individual factor can change during the course of the disease
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Table of contents (13 chapters)
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- F. Melchers, A. R. Rolink
Pages 1-23
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- S. Sakaguchi, R. Setoguchi, H. Yagi, T. Nomura
Pages 51-66
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- J. F. G. Cohen-Solal, V. Jeganathan, C. M. Grimaldi, E. Peeva, B. Diamond
Pages 67-88
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- D. J. B. Marks, N. A. Mitchison, A. W. Segal, J. Sieper
Pages 105-125
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- S. Brydges, D. L. Kastner
Pages 127-160
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- U. S. Gaipl, A. Sheriff, S. Franz, L. E. Munoz, R. E. Voll, J. R. Kalden et al.
Pages 161-176
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- F. M. Brennan, A. D. Foey, M. Feldmann
Pages 177-194
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- A. Skapenko, P. E. Lipsky, H. Schulze-Koops
Pages 195-211
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- R. A. Manz, K. Moser, G. -R. Burmester, A. Radbruch, F. Hiepe
Pages 241-257
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- M. Johannesson, M. Hultqvist, R. Holmdahl
Pages 259-276
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Back Matter
Pages 277-282
About this book
The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance of the development of potentially pathogenic self-reactivity. Despite this, the development of self-reactivity is relatively common. - though the development of autoimmune disease is less frequent, autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus e- thematosus, psoriasis, thyroiditis, and myasthenia gravis, are all too common, and can cause considerable morbidity and even mortality.
Editors and Affiliations
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Deutsches Rheumaforschungszentrum Berlin (DRFZ), Berlin, Germany
Andreas Radbruch
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National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, USA
Peter E. Lipsky