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Table of contents

  1. Front Matter
    Pages I-VII
  2. C. A. Stewart, E. Vivier, M. Colonna
    Pages 1-21
  3. A.W. MacFarlane IV, K. S. Campbell
    Pages 23-57
  4. M. E. McNerney, V. Kumar
    Pages 91-120
  5. S. González, V. Groh, T. Spies
    Pages 121-138
  6. L. Zitvogel, M. Terme, C. Borg, G. Trinchieri
    Pages 157-174
  7. C. Bottino, L. Moretta, A. Moretta
    Pages 175-182
  8. S. M. Vidal, L. L. Lanier
    Pages 183-206
  9. M. Gumá, A. Angulo, M. López-Botet
    Pages 207-223
  10. M. Carrington, M. P. Martin
    Pages 225-257
  11. S. Johansson, H. Hall, L. Berg, P. Höglund
    Pages 259-277
  12. Back Matter
    Pages 279-283

About this book

Introduction

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Keywords

Chemokine NK cells autoimmune disease bacteria biology cell cells gene immunobiology immunoglobulin infection parasite pathology tissue virus

Editors and affiliations

  • R.W. Compans
    • 1
  • M.D. Cooper
    • 2
  • T. Honjo
    • 3
  • H. Koprowski
    • 4
  • F. Melchers
    • 5
  • M.B.A. Oldstone
    • 6
  • S. Olsnes
    • 7
  • M. Potter
    • 8
  • P.K. Vogt
    • 9
  • H. Wagner
    • 10
  • Eric Vivier
    • 11
  • Marco Colonna
    • 12
  1. 1.Atlanta
  2. 2.Birmingham
  3. 3.Kyoto
  4. 4.Philadelphia
  5. 5.Basel
  6. 6.La Jolla
  7. 7.Oslo
  8. 8.Bethesda
  9. 9.La Jolla
  10. 10.Munich
  11. 11.Laboratory of NK Cells and Innate Immunity, Centre d’Immunologie de Marseille-Luminy (CIML)CNRS-INSERM-Université de la Méditerranée, Campus de LuminyMarseille Cedex 09France
  12. 12.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA

Bibliographic information