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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

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  • © 2005

Overview

Editors:
  1. R.W. Compans

    1. Atlanta

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  2. M.D. Cooper

    1. Birmingham

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  3. T. Honjo

    1. Kyoto

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  4. H. Koprowski

    1. Philadelphia

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  5. F. Melchers

    1. Basel

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  6. M.B.A. Oldstone

    1. La Jolla

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  7. S. Olsnes

    1. Oslo

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  8. M. Potter

    1. Bethesda

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  9. P.K. Vogt

    1. La Jolla

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  10. H. Wagner

    1. Munich

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  11. Bruno Kyewski

    1. Abteilung Entwicklungsimmunologie, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Heidelberg, Germany

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  12. Elisabeth Suri-Payer

    1. Abteilung Immungenetik, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Heidelberg, Germany

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 293)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Origin and Generation

    1. Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides

      • C. Cozzo, M. A. Lerman, A. Boesteanu, J. Larkin III, M. S. Jordan, A. J. Caton
      Pages 1-23

    2. The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

      • C.-S. Hsieh, A. Y. Rudensky
      Pages 25-42

    3. Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection

      • A. Coutinho, I. Caramalho, E. Seixas, J. Demengeot
      Pages 43-71

    4. Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models

      • L. Klein, J. Emmerich, L. d’Cruz, K. Aschenbrenner, K. Khazaie
      Pages 73-87

    5. Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets

      • J. Huehn, K. Siegmund, A. Hamann
      Pages 89-114

    6. Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells

      • L. S. Taams, A. N. Akbar
      Pages 115-131

    7. Dendritic Cells: Key Cells for the Induction of Regulatory T Cells?

      • K. Mahnke, A. H. Enk
      Pages 133-150

  3. Involvement of Disease Models

    1. Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression

      • R. S. McHugh
      Pages 153-177

    2. Regulatory T Cells in Experimental Colitis

      • M. Gad
      Pages 179-208

    3. Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control

      • K. S. K. Tun, Y. Y. Setiady, E. T. Samy, J. Lewis, C. Teuscher
      Pages 209-247

    4. Regulatory T Cells in Transplantation Tolerance

      • H. Waldmann, L. Graca, E. Adams, P. Fairchild, S. Cobbold
      Pages 249-264

    5. CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation

      • P. Hoffmann, J. Ermann, M. Edinger
      Pages 265-285

    6. Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

      • T. Nomura, S. Sakaguchi
      Pages 287-302

    7. Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells

      • M. K. Levings, M. G. Roncarolo
      Pages 303-326

  4. Back Matter

    Pages 327-330
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Keywords

About this book

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.

The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Editors and Affiliations

  • Atlanta

    R.W. Compans

  • Birmingham

    M.D. Cooper

  • Kyoto

    T. Honjo

  • Philadelphia

    H. Koprowski

  • Basel

    F. Melchers

  • La Jolla

    M.B.A. Oldstone, P.K. Vogt

  • Oslo

    S. Olsnes

  • Bethesda

    M. Potter

  • Munich

    H. Wagner

  • Abteilung Entwicklungsimmunologie, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Heidelberg, Germany

    Bruno Kyewski

  • Abteilung Immungenetik, Deutsches Krebsforschungszentrum Forschungsschwerpunkt Tumorimmunologie, Heidelberg, Germany

    Elisabeth Suri-Payer

Bibliographic Information

  • Book Title: CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

  • Editors: R.W. Compans, M.D. Cooper, T. Honjo, H. Koprowski, F. Melchers, M.B.A. Oldstone, S. Olsnes, M. Potter, P.K. Vogt, H. Wagner, Bruno Kyewski, … Elisabeth Suri-Payer

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/3-540-27702-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2005

  • Hardcover ISBN: 978-3-540-24444-8Published: 23 May 2005

  • Softcover ISBN: 978-3-642-06376-3Published: 21 October 2010

  • eBook ISBN: 978-3-540-27702-6Published: 09 January 2006

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 332

  • Number of Illustrations: 6 b/w illustrations, 12 illustrations in colour

  • Topics: Immunology

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