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Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy

  • Book
  • © 2007


  • A comprehensive treatise of COX-2, inflammation and disease
  • A spell-binding look at the COX-2 controversy
  • New and exciting findings on COX-2 blockade in cancer prevention and therapy as well as the prevention of Alzheimer’s disease and other neurodegenerative conditions
  • COX-2 and the inflammogenesis of cancer

Part of the book series: Subcellular Biochemistry (SCBI, volume 42)

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Table of contents (14 chapters)

  1. Historical Perspectives

  2. Inflammatory Mechanisms of Pathogenesis

  3. Inflammation and Cardiovascular Disease: The Coxib Controversy

  4. Cox-2 Blockade in Cancer Prevention and Therapy

  5. Inflammation and Neurodegenerative Disease

  6. Nutrition, Inflammation and Chronic Disease


From the reviews: “This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. … Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. … It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)

Editors and Affiliations

  • Center of Molecular Epidemiology and Environmental Health, College of Medicine and School of Public Health, The Ohio State University Medical Center, Columbus, USA

    Randall E. Harris

  • Queens College, City University of New York, New York, USA

    R. Bittman

  • Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  • Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt, P. Zwickl

  • MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  • German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  • Texas A&M University, USA

    A. Holzenburg

  • National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  • The Hebrew University, Israel

    S. Rottem

  • DSM Nutritional Products Ltd., Basel, Switzerland

    M. Wyss

Bibliographic Information

  • Book Title: Inflammation in the Pathogenesis of Chronic Diseases

  • Book Subtitle: The COX-2 Controversy

  • Editors: Randall E. Harris, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, P. Zwickl

  • Series Title: Subcellular Biochemistry

  • DOI:

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2007

  • Hardcover ISBN: 978-1-4020-5687-1Published: 17 April 2007

  • Softcover ISBN: 978-90-481-7429-4Published: 22 November 2010

  • eBook ISBN: 978-1-4020-5688-8Published: 09 May 2007

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XIV, 324

  • Topics: Pharmacology/Toxicology, Cancer Research, Pathology, Cardiology, Neurology, Immunology

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