RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS

  • HEINZ H. COENEN
  • JOHN MERTENS
  • BERNARD MAZIEÈRE

Table of contents

  1. Front Matter
    Pages i-x
  2. Pages 1-4
  3. Pages 87-91

About this book

Introduction

Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them.

The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radio-iodination reactions.

Keywords

Isotop Nucleophilic substitution metals pharmaceuticals radioactivity

Editors and affiliations

  • HEINZ H. COENEN
    • 1
  • JOHN MERTENS
    • 2
  • BERNARD MAZIEÈRE
    • 3
  1. 1.Research Centre Juülich (FZJ)Institute of Nuclear ChemistryGermany
  2. 2.BEFY/NUGE – Radiopharmaceutical ChemistryBelgium
  3. 3.Département de Biologie Service Hospitalier Frederic-JoliotCEA/DRIPPFrance

Bibliographic information

  • DOI https://doi.org/10.1007/1-4020-4561-1
  • Copyright Information Springer Science+Business Media B.V. 2006
  • Publisher Name Springer, Dordrecht
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-1-4020-4560-8
  • Online ISBN 978-1-4020-4561-5
  • About this book