Learning from Nature How to Design New Implantable Biomaterialsis: From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes

Proceedings of the NATO Advanced Study Institute, held in Alvor, Algarve, Portugal, 13–24 October 2003

  • R. L. Reis
  • S. Weiner

Part of the NATO Science Series II: Mathematics, Physics and Chemistry book series (NAII, volume 171)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Structure and Mechanical Functions in Biological Materials

  3. Bioceramics, Bioactive Materials and Surface Analysis

  4. Biomimetics and Biomimetic Coatings

    1. B. Ben-Nissan
      Pages 89-103
    2. I. B. Leonor, H. S. Azevedo, I. Pashkuleva, A. L. Oliveira, C. M. Alves, R. L. Reis
      Pages 123-150
    3. J. Aizenberg, G. Hendler
      Pages 151-166
  5. Tissue Engineering of Mineralized Tissues

    1. Paul Calvert, Yuka Yoshioka, Ghassan Jabbour
      Pages 169-180
    2. Robert C. Bielby, Julia M. Polak
      Pages 181-198
    3. A. J. Salgado, M. E. Gomes, R. L. Reis
      Pages 205-222
  6. Back Matter
    Pages 223-233

About these proceedings


The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable interest as natural anisotropic composite structures with adequate mechanical properties. In fact, Nature is and will continue to be the best materials scientist ever. Who better than nature can design complex structures and control the intricate phenomena (processing routes) that lead to the final shape and structure (from the macro to the nano level) of living creatures? Who can combine biological and physico-chemical mechanisms in such a way that can build ideal structure-properties relationships? Who, else than Nature, can really design smart structural components that respond in-situ to exterior stimulus, being able of adapting constantly their microstructure and correspondent properties? In the described philosophy line, mineralized tissues and biomineralization processes are ideal examples to learn-from for the materials scientist of the future.


Biomaterial Brainstorming Natur Tissue Engineering biomedical materials bone cells science tissue

Editors and affiliations

  • R. L. Reis
    • 1
  • S. Weiner
    • 2
  1. 1.Department of Polymer EngineeringUniversity of MinhoBragaPortugal
  2. 2.Department of Structural BiologyWeizmann Institute of ScienceRehovotIsrael

Bibliographic information