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  • Book
  • © 2006

Power Laws, Scale-Free Networks and Genome Biology

  • The first such compendium in the field

  • Contributed by leading researchers in the field

  • Balanced coverage of the emerging field of Theoretical Systems Biology, accessibility to researchers with limited mathematical background combined with thorough presentation

  • Contains chapter summaries

  • Contains detailed illustrations

  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xix
  2. Power Laws in Biological Networks

    • Eivind Almaas, Albert-László Barabási
    Pages 1-11
  3. Graphical Analysis of Biocomplex Networks and Transport Phenomena

    • Kwang-Il Goh, Byungnam Kahng, Doochul Kim
    Pages 12-24
  4. Large-Scale Topological Properties of Molecular Networks

    • Sergei Maslov, Kim Sneppen
    Pages 25-39
  5. The Connectivity of Large Genetic Networks

    • Andreas Wagner
    Pages 40-52
  6. Birth and Death Models of Genome Evolution

    • Georgy P. Karev, Yuri I. Wolf, Eugene V. Koonin
    Pages 65-85
  7. Scale-Free Evolution

    • Nikolay V. Dokholyan, Eugene I. Shakhnovich
    Pages 86-105
  8. Gene Regulatory Networks

    • T. Gregory Dewey, David J. Galas
    Pages 106-122
  9. Power Law Correlations in DNA Sequences

    • Sergey V. Buldyrev
    Pages 123-164
  10. The Protein Universes

    • S. Rackovsky
    Pages 194-205
  11. The Role of Computation in Complex Regulatory Networks

    • Pau Fernández, Ricard V. Solé
    Pages 206-225
  12. Scaling Laws in the Functional Content of Genomes

    • Erik van Nimwegen
    Pages 236-253
  13. Back Matter

    Pages 255-257

About this book

Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.

Keywords

  • DNA
  • evolution
  • genes
  • genetics
  • genome
  • mathematical modeling
  • molecular biology
  • protein
  • regulation
  • transcription
  • Proteomics

Authors and Affiliations

  • National Center for Biotechnology Information National Library of Medicine, National Institutes of Health, Bethesda, USA

    Eugene V. Koonin, Yuri I. Wolf, Georgy P. Karev

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (Canada)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (Canada)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (Canada)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access