Tissue Repair, Contraction and the Myofibroblast

  • Christine Chaponnier
  • Alexis Desmoulière
  • Giulio Gabbiani

Part of the Biotechnology Intelligence Unit book series (BIOIU)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Alexis Desmoulière, Christine Chaponnier, Giulio Gabbiani
    Pages 1-6
  3. Galina S. Bogatkevich, Anna Ludwicka-Bradley, Paul J. Nietert, Richard M. Silver
    Pages 25-31
  4. Carolyn J. Baglole, Terry J. Smith, David Foster, Patricia J. Sime, Steve Feldon, Richard P. Phipps
    Pages 32-39
  5. Sabrina Mattoli
    Pages 40-46
  6. Michael Zeisberg, Mary A. Soubasakos, Raghu Kalluri
    Pages 47-52
  7. Abelardo Aguilera, Luiz S. Aroeira, Marta Ramírez-Huesca, José A. Jiménez-Heffernan, Rafael Selgas, Manuel López-Cabrera
    Pages 53-67
  8. Elvira Olaso, Beatriz Arteta, Clarisa Salado, Eider Eguilegor, Natalia Gallot, Aritz Lopategi et al.
    Pages 88-101
  9. Dianhua Jiang, Jennifer Hodge, Jiurong Liang, Paul W. Noble
    Pages 110-117
  10. James V. Jester
    Pages 118-138
  11. Back Matter
    Pages 139-141

About this book


hirty-four years after the first description of the myofibroblast, the number of publications concerning this cell is very impressive and Tcontinuously expanding, and the work on the myofibroblast involves many laboratories throughout the world. The myofibroblast has been implicated in developmental and physiological phenomena, as well as in a variety of pathological situations, going from wound healing and fibrotic changes to asthma and cancer invasion. Many aspects of myofibroblast biology have been clarified, such as the role of TGF-P and ED-A cellular fibronectin in its differentiation and the role of a-smooth muscle actin in tension production by this cell; however several important problems concerning myofibroblast origin, ftmction and participation in pathological processes remain to be solved. The purpose of this book, as well of the Meeting "Tissue Repair, Contraction and the Myofibroblast" that took place in Nyon, near Geneva, Switzerland on November 18-20, 2004, is to put together the most recent advances in the understanding of myofibroblast biology and to present the main directions of research taking place worldwide to explore new aspects of myofibroblast physiological and pathological activities, such as: mechanisms of force generation by the myofibroblast; myofibroblast origin and diversity; interaction of the myofibroblast with other cells, normal and malignant epithelial cells in particular; and participation of the myofibroblast in the development of fibrosis in various organs. If we consider the animated and constructive discussions that took place during the Nyon Meeting, we are sure that this book will inspire new research in these fields.


asthma biology cancer cell cell biology development evolution eye glycoprotein membrane pathology protein regulation tissue tumor

Authors and affiliations

  • Christine Chaponnier
    • 1
  • Alexis Desmoulière
    • 2
  • Giulio Gabbiani
    • 1
  1. 1.Department of Pathology and ImmunologyUniversity of GenevaGenevaSwitzerland
  2. 2.Inserm E362University of Bordeaux 2BordeauxFrance

Bibliographic information