The Local Cardiac Renin Angiotensin-Aldosterone System

  • Edward D. Frohlich
  • Richard N. Re

Part of the Basic Science for the Cardiologist book series (volume 20)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Nathalie L’Huillier, Matthew G. F. Sharp, Donald R. Dunbar, John J. Mullins
    Pages 17-34
  3. Robert M. Carey, Helmy M. Siragy
    Pages 35-43
  4. L. Gabriel Navar, Minolfa C. Prieto-Carrasquero, Hiroyuki Kobori
    Pages 45-59
  5. Christine Hubert, Katia Savary, Jean-Marie Gasc, Pierre Corvol
    Pages 99-110
  6. Sandhya Sanghi, David E. Dostal
    Pages 111-127
  7. Patricia E. Gallagher, E. Ann Tallant, Carlos M. Ferrario
    Pages 129-142
  8. Muhammad T. Gill, Jaiwei Chen, J. L. Mehta
    Pages 143-162
  9. Tatjana Ignjatovic, Sinisa Stanisavljevic, Viktor Brovkovych, Fulong Tan, Randal A. Skidgel, Ervin G. Erdös
    Pages 163-176
  10. Arantxa González, Begoña López, Ramón Querejeta, Javier Díez
    Pages 177-189
  11. Bernard Swynghedauw, Christophe Heymes, Claude Delcayre
    Pages 191-199
  12. Back Matter
    Pages 219-224

About these proceedings


How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain.


arterial pressure cardiovascular circulation heart hypertension

Editors and affiliations

  • Edward D. Frohlich
    • 1
  • Richard N. Re
    • 1
  1. 1.Ochsner Clinic FoundationNew OrleansUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, Inc. 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-0-387-27825-4
  • Online ISBN 978-0-387-27826-1
  • Series Print ISSN 1566-0753
  • Buy this book on publisher's site