Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

  • Henry Jay Forman
  • Jon Fukuto
  • Martine Torres

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Chemical Principles in Reactive Oxygen and Nitrogen Signaling

  3. Redox Signaling

    1. Rebecca S. Arnold, J. David Lambeth
      Pages 102-118
    2. Ulrich Forstermann, Huige Li, Petra M. Schwarz, Hartmut Kleinert
      Pages 119-154
    3. Joseph Loscalzo
      Pages 155-166
    4. Sue Goo Rhee, Seung-Rock Lee, Kap-Seok Yang, Jaeyul Kwon, Sang Won Kang
      Pages 167-179
    5. Giuseppe Poll, Gabriella Leonarduzzi, Elena Charpotto
      Pages 180-193
    6. Tzipora Goldkorn, Tommer Ravid, Edward A Medina
      Pages 194-222
    7. Atsushi Matsuzawa, Hideki Nishitoh, Kohsuke Takeda, Hidenori Ichijo
      Pages 223-236
    8. Xue Zhang, Gark Garfinkel, Douglas Ruden
      Pages 256-274
  4. Physiology and Pathophysiology

    1. Sruti Shiva, Anna-Liisa Levonen, Maria Cecilia Barone, Victor M. Darley-Usmar
      Pages 275-290
    2. Victor J. Thannickal, Barryl Fanburg
      Pages 291-310
    3. Cecilia Giulivi, Merry Jo Oursler
      Pages 311-332
    4. Timothy P. Dalton, Lei He, Howard G. Shertzer, Alvaro Puga
      Pages 333-364
  5. Back Matter
    Pages 407-411

About this book


Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.


Activation Drogen Regulation biochemistry biosynthesis conservation enzymes gene expression genes hydrogen peroxide physiology signal transduction transcription

Editors and affiliations

  • Henry Jay Forman
    • 1
  • Jon Fukuto
    • 2
  • Martine Torres
    • 3
  1. 1.University of Alabama at BirminghamBirminghamUSA
  2. 2.University of California at Los AngelesLos AngelesUSA
  3. 3.Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

Bibliographic information