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Self-Assembling Peptide Systems in Biology, Medicine and Engineering

  • Amalia Aggeli
  • Neville Boden
  • Shuguang Zhang

Table of contents

  1. Front Matter
    Pages i-xii
  2. A. Aggeli, I. A. Nyrkova, M. Bell, L. Carrick, T. C. B. Mcleish, A. N. Semenov et al.
    Pages 1-17
  3. S. E. Blondelle, E. Crooks, N. Reixach, E. Pérez-Payá
    Pages 35-45
  4. Nicholas J. Gay, Martyn Symmons, Marisa Martin-Fernandez, Gareth Jones
    Pages 113-125
  5. M.H. Hecht, M.W. Rest, J. Patterson, J.D. Mancias, J.R. Beasley, B.M. Broome et al.
    Pages 127-138
  6. H. Mihara, Y. Takahashi, I. Obataya, S. Sakamoto
    Pages 187-205
  7. Anna Mitraki, Mark Van Raaij, Rob Ruigrok, Stephen Cusack, Jean-Francois Hernandez, Mary Luckey
    Pages 221-234
  8. A. Rich
    Pages 235-241
  9. Miriam Royo, Miquel Àngel Contreras, Juan Cebrián, Ernest Giralt, Fernando Albericio, Miquel Pons
    Pages 243-256
  10. Marta Sakarellos-Daitsiotis, Vassilios Tsikaris, Constantinos Sakarellos
    Pages 257-271
  11. Mark S. Spector, Ronald R. Price, Joel M. Schnur
    Pages 311-321
  12. Dan W. Urry, Larry Haye, Chixiang Luan, D. Channe Gowda, David McPherson, Jie Xu et al.
    Pages 323-342
  13. Shuguang Zhang, Michael Altman
    Pages 343-360
  14. Back Matter
    Pages 361-364

About this book

Introduction

One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.

Keywords

Biopolymer Lipid Tissue Engineering biomedical engineering membrane proteins polymer proteins thermodynamics

Authors and affiliations

  • Amalia Aggeli
    • 1
  • Neville Boden
    • 1
  • Shuguang Zhang
    • 2
  1. 1.University of LeedsUK
  2. 2.Massachusetts Institute of TechnologyCambridgeUSA

Bibliographic information