Engineering and Manufacturing for Biotechnology

  • Marcel Hofman
  • Philippe Thonart

Part of the Focus on Biotechnology book series (FOBI, volume 4)

Table of contents

  1. Front Matter
    Pages i-18
  2. Upstream Processes and Fermentation

    1. Front Matter
      Pages 19-19
    2. Güzide Çalik, Meliha Berk, Fatma Gül Boyaci, Pinar Çalik, Serpil Takaç, Tunçer H. Özdamar
      Pages 21-28
    3. Fabienne Guerard, Rozenn Ravakkec-Ple, Denis De La Broise, Adrien Binet, Laurent Dufosse
      Pages 39-50
    4. Rozenn Ravallec-Ple, Laura Gilmartin, Alain Van Wormhoudt, Yves Le Gak
      Pages 51-58
  3. Process Modelling

    1. Front Matter
      Pages 59-59
    2. R. Takors, D. Weuster-Botz, W. Wiechert, C. Wandrey
      Pages 111-128
    3. J. M. Urrieta-Saltijeral, C. G. Dussap, A. Pons, C. Creuly, J. B. Gros
      Pages 143-156
  4. Integrated Processes

    1. Front Matter
      Pages 169-169
    2. Serpil TakaÇ, Sema Elmas, Pinar Çalik, TunÇer H. Özdamar
      Pages 171-179
  5. Monitoring and Control

    1. Front Matter
      Pages 181-181
    2. K. Pouliot, J. Thibault, A. Garnier, G. Acuna Leiva
      Pages 183-201
    3. J.-F Cornet, C. G. Dussap, J.-J. Leclercq
      Pages 227-238
  6. Reactor Engineering

    1. Front Matter
      Pages 239-239
    2. Isabelle Walther, Bart Van der Schoot, Marc Boillat, Augusto Cogoli
      Pages 241-251
  7. Immobilisation and Permeabilisation

    1. Front Matter
      Pages 253-253
    2. C. A. Masschelein, J. Vandenbussche
      Pages 255-276
    3. Viktor A. Nedovic, Bojana Obradovic, Ida Leskosek-Cukalovic, Gordana Vunjak-Novakovic
      Pages 277-292
    4. Ulrich Jahnz, Peter Wittlich, Ulf Prüsse, Klaus-Dieter Vorlop
      Pages 293-307
  8. Downstream Processing

    1. Front Matter
      Pages 309-309
    2. Mads Laustsen
      Pages 311-324
    3. S. L. Lucena, P. T. V. Rosa, L. T. Furlan, C. C. Santana
      Pages 325-337
    4. Silvia Andrea Camperi, Mariano Grasselli, Osvaldo Cascone
      Pages 339-349
  9. Economic Finalities

    1. Front Matter
      Pages 351-351
    2. Marlene Etschmann, Peter Gebhart, Dieter Sell
      Pages 353-360
    3. Weekers F., Jacques P., Mergeay M., Thonart P.
      Pages 383-398
    4. Heike Neubaier, Beat Mollet
      Pages 399-412
    5. Remy Cachon, Charles Divies
      Pages 413-421
    6. Hideki Fukuda, Akihiko Kondo, Hideo Noda
      Pages 449-455
  10. Patents and Licenses

    1. Front Matter
      Pages 457-457
  11. Back Matter
    Pages 487-490

About this book


Early integration is the key to success in industrial biotechnology. This is as true when a selected wild-type organism is put to work as when an organism is engineered for a purpose.
The present volume Engineering and Manufacturing for Biotechnology took advantage of the 9th European Congress on Biotechnology (Brussels, Belgium, July 11-15, 1999): in the topics handled and in the expertise of the contributors, the engineering science symposia of this congress offered just what was needed to cover the important topic of integration of process engineering and biological research.
The editors have solicited a number of outstanding contributions to illustrate the intimate interaction between productive organisms and the numerous processing steps running from the initial inoculation to the packaged product. Upstream processing of the feed streams, selection of medium components, product harvesting, downstream processing, and product conditioning are just a few major steps. Each step imposes a number of important choices. Every choice is to be balanced against time to market, profitability, safety, and ecology.


Downstream Processing Fermentation Filtration Polysaccharid Polysaccharide biotechnology enzymes genetic engineering proteins ultrafiltration

Editors and affiliations

  • Marcel Hofman
    • 1
  • Philippe Thonart
    • 2
  1. 1.Société de Chimie IndustrielleCentre for Veterinary and Agrochemical ResearchTervurenBelgium
  2. 2.Faculté Univ. des Sciences Agronomiques GemblouxCentre Wallon de Biologie IndustrielleBelgium

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-6927-1
  • Online ISBN 978-0-306-46889-6
  • Series Print ISSN 1569-268X
  • Buy this book on publisher's site