Zinc Finger Proteins

From Atomic Contact to Cellular Function

  • Shiro Iuchi
  • Natalie Kuldell

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account

  3. Binding of Zinc Fingers to DNA

    1. Raymond S. Brown, Jane Flint
      Pages 14-19
    2. G. Marius Clore, James G. Omichinski
      Pages 20-25
    3. Ryoji Masui, Noriko Nakagawa, Seiki Kuramitsu
      Pages 31-34
    4. Patrick Van Roey, Marlene Belfort, Victoria Derbyshire
      Pages 35-38
    5. Jay S. Hanas, Jason L. Larabee, James R. Hocker
      Pages 39-46
    6. Nicoletta Corbi, Valentina Libri, Claudio Passananti
      Pages 47-55
  4. Binding of Zinc Fingers to RNA

    1. Paul J. Romaniuk
      Pages 56-65
    2. Martyn K. Darby
      Pages 66-75
    3. Cristina Mendez-Vidal, Fredrik Hellborg, Margareta T. Wilhelm, Magdalena Tarkowska, Klas G. Wiman
      Pages 76-79
    4. Perry J. Blackshear, Ruth S. Phillips, Wi S. Lai
      Pages 80-90
    5. John Dresios, Yuen-Ling Chan, Ira G. Wool
      Pages 91-98
  5. Binding of Zinc Fingers to Proteins

    1. Algirdas Velyvis, Jun Qin
      Pages 99-105
    2. Roberto N. De Guzman, Maria A. Martinez-Yamout, H. Jane Dyson, Peter E. Wright
      Pages 114-120
    3. Odile Filhol, Maria José Benitez, Claude Cochet
      Pages 121-127
  6. Binding of Zinc Fingers to Small Molecules

About this book

Introduction

In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.

Keywords

DNA RNA gene expression genes protein family proteins ribosomal RNA signal transduction transcription

Editors and affiliations

  • Shiro Iuchi
    • 1
  • Natalie Kuldell
    • 2
  1. 1.Department of Cell BiologyHarvard Medical SchoolBostonUSA
  2. 2.Biological Engineering DivisionMassachusetts Institute of TechnologyCambridgeUSA

Bibliographic information

  • DOI https://doi.org/10.1007/b139055
  • Copyright Information Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers 2005
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-306-48229-8
  • Online ISBN 978-0-387-27421-8
  • About this book